U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nabp1 nucleic acid binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363227, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Nabp1provided by RGD
Official Full Name
nucleic acid binding protein 1provided by RGD
Primary source
RGD:1306658
See related
Ensembl:ENSRNOG00000015416 AllianceGenome:RGD:1306658
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Obfc2a; RGD1306658
Summary
Predicted to enable RNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; mitotic G2/M transition checkpoint; and response to ionizing radiation. Predicted to be located in chromosome; cytosol; and nucleoplasm. Predicted to be part of SOSS complex. Orthologous to human NABP1 (nucleic acid binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 225.6), Thymus (RPKM 225.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (57570326..57625926)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (50098552..50133982)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (55049893..55057784)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL11-like Neighboring gene uncharacterized LOC134480572 Neighboring gene transfer RNA alanine (anticodon AGC) 29 Neighboring gene large ribosomal subunit protein uL14-like Neighboring gene uncharacterized LOC120094683

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NABP1, a novel RORgamma-regulated gene encoding a single-stranded nucleic-acid-binding protein. Kang HS, et al. Biochem J, 2006 Jul 1. PMID 16533169, Free PMC Article
  2. Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres. Gu P, et al. Cell Res, 2013 May. PMID 23459151, Free PMC Article
  3. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. Li Y, et al. J Biol Chem, 2009 Aug 28. PMID 19605351, Free PMC Article
  4. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Richard DJ, et al. Nature, 2008 May 29. PMID 18449195
  5. SOSS complexes participate in the maintenance of genomic stability. Huang J, et al. Mol Cell, 2009 Aug 14. PMID 19683501, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC108887

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic G2/M transition checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2/M transition checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic cell cycle checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SOSS complex ISO
Inferred from Sequence Orthology
more info
  
part_of SOSS complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SOSS complex subunit B2
Names
SOSS-B2
oligonucleotide/oligosaccharide-binding fold containing 2A
oligonucleotide/oligosaccharide-binding fold-containing protein 2A
sensor of single-strand DNA complex subunit B2
sensor of ssDNA subunit B2
single-stranded DNA-binding protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014216.2 → NP_001014238.1  SOSS complex subunit B2

    See identical proteins and their annotated locations for NP_001014238.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5FVP2
    UniProtKB/TrEMBL
    A6INX2
    Related
    ENSRNOP00000021403.3, ENSRNOT00000021403.6
    Conserved Domains (1) summary
    cd04491
    Location:22 → 99
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    57570326..57625926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267373.1 → XP_063123443.1  SOSS complex subunit B2 isoform X1

    UniProtKB/TrEMBL
    A6INX4

  2. XM_039083850.2 → XP_038939778.1  SOSS complex subunit B2 isoform X3

    Conserved Domains (1) summary
    cd04491
    Location:4 → 73
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

  3. XM_017596514.3 → XP_017452003.1  SOSS complex subunit B2 isoform X1

    UniProtKB/TrEMBL
    A6INX4

  4. XM_039083849.2 → XP_038939777.1  SOSS complex subunit B2 isoform X2

    Conserved Domains (1) summary
    cd04491
    Location:22 → 99
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

  5. XM_039083851.2 → XP_038939779.1  SOSS complex subunit B2 isoform X1

    UniProtKB/TrEMBL
    A6INX4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVP2.1 GenPept UniProtKB/Swiss-Prot:Q5FVP2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous