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Cpeb2 cytoplasmic polyadenylation element binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360949, updated on 11-Apr-2024

Summary

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Official Symbol
Cpeb2provided by RGD
Official Full Name
cytoplasmic polyadenylation element binding protein 2provided by RGD
Primary source
RGD:1307485
See related
Ensembl:ENSRNOG00000005043 AllianceGenome:RGD:1307485
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables GTPase inhibitor activity; ribosomal large subunit binding activity; and ribosomal small subunit binding activity. Involved in negative regulation of GTPase activity. Predicted to be part of messenger ribonucleoprotein complex and polysome. Predicted to be active in several cellular components, including neuron projection; nucleus; and synapse. Orthologous to human CPEB2 (cytoplasmic polyadenylation element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 130.6), Brain (RPKM 104.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14q21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (71999958..72056012, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (67787503..67839973, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (72327929..72382519, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481850 Neighboring gene iron-sulfur cluster assembly 2, pseudogene 1 Neighboring gene uncharacterized LOC103693081 Neighboring gene uncharacterized LOC134481851

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression. Hägele S, et al. Biochem J, 2009 Jan 1. PMID 18752464
  2. CPEB2, a novel putative translational regulator in mouse haploid germ cells. Kurihara Y, et al. Biol Reprod, 2003 Jul. PMID 12672660
  3. A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. Peng SC, et al. Nucleic Acids Res, 2010 Nov. PMID 20639532, Free PMC Article
  4. CPEB2-eEF2 interaction impedes HIF-1α RNA translation. Chen PJ, et al. EMBO J, 2012 Feb 15. PMID 22157746, Free PMC Article
  5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA regulatory element binding translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA regulatory element binding translation repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity ISO
Inferred from Sequence Orthology
more info
  
enables poly-pyrimidine tract binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosomal large subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal small subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytoplasmic translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cytoplasmic translational elongation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of translational elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation at synapse, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytoplasmic polyadenylation element-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    71999958..72056012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092809.2 → XP_038948737.1  cytoplasmic polyadenylation element-binding protein 2 isoform X13

    Conserved Domains (3) summary
    pfam16366
    Location:910 → 971
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:727 → 818
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:835 → 915
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  2. XM_039092807.2 → XP_038948735.1  cytoplasmic polyadenylation element-binding protein 2 isoform X11

    Conserved Domains (3) summary
    pfam16366
    Location:918 → 979
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:735 → 826
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:843 → 923
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  3. XM_039092804.2 → XP_038948732.1  cytoplasmic polyadenylation element-binding protein 2 isoform X8

    Conserved Domains (3) summary
    pfam16366
    Location:932 → 993
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:749 → 840
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:857 → 937
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  4. XM_063273830.1 → XP_063129900.1  cytoplasmic polyadenylation element-binding protein 2 isoform X14

  5. XM_039092802.2 → XP_038948730.1  cytoplasmic polyadenylation element-binding protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y989
    Related
    ENSRNOP00000076988.1
    Conserved Domains (3) summary
    pfam16366
    Location:940 → 1001
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:757 → 848
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:865 → 945
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  6. XM_039092799.2 → XP_038948727.1  cytoplasmic polyadenylation element-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    D3ZHK8
    Related
    ENSRNOP00000006727.8
    Conserved Domains (3) summary
    pfam16366
    Location:948 → 1009
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:765 → 856
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:873 → 953
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  7. XM_039092797.2 → XP_038948725.1  cytoplasmic polyadenylation element-binding protein 2 isoform X2

    Conserved Domains (3) summary
    pfam16366
    Location:962 → 1023
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:779 → 870
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:887 → 967
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  8. XM_039092808.2 → XP_038948736.1  cytoplasmic polyadenylation element-binding protein 2 isoform X12

    Conserved Domains (3) summary
    pfam16366
    Location:913 → 974
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:730 → 821
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:838 → 918
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  9. XM_039092806.2 → XP_038948734.1  cytoplasmic polyadenylation element-binding protein 2 isoform X10

    Conserved Domains (3) summary
    pfam16366
    Location:921 → 982
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:738 → 829
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:846 → 926
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  10. XM_039092803.2 → XP_038948731.1  cytoplasmic polyadenylation element-binding protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K520
    Related
    ENSRNOP00000073259.2
    Conserved Domains (3) summary
    pfam16366
    Location:935 → 996
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:752 → 843
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:860 → 940
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  11. XM_039092801.2 → XP_038948729.1  cytoplasmic polyadenylation element-binding protein 2 isoform X5

    Conserved Domains (3) summary
    pfam16366
    Location:943 → 1004
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:760 → 851
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:868 → 948
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  12. XM_039092798.2 → XP_038948726.1  cytoplasmic polyadenylation element-binding protein 2 isoform X3

    Conserved Domains (3) summary
    pfam16366
    Location:951 → 1012
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:768 → 859
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:876 → 956
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  13. XM_039092805.2 → XP_038948733.1  cytoplasmic polyadenylation element-binding protein 2 isoform X9

    Conserved Domains (3) summary
    pfam16366
    Location:965 → 1004
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:782 → 873
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:890 → 970
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  14. XM_039092796.2 → XP_038948724.1  cytoplasmic polyadenylation element-binding protein 2 isoform X1

    Conserved Domains (3) summary
    pfam16366
    Location:965 → 1026
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:782 → 873
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:890 → 970
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  15. XM_063273833.1 → XP_063129903.1  cytoplasmic polyadenylation element-binding protein 2 isoform X18

  16. XM_063273832.1 → XP_063129902.1  cytoplasmic polyadenylation element-binding protein 2 isoform X17

  17. XM_063273831.1 → XP_063129901.1  cytoplasmic polyadenylation element-binding protein 2 isoform X16

  18. XM_039092810.2 → XP_038948738.1  cytoplasmic polyadenylation element-binding protein 2 isoform X15

    UniProtKB/TrEMBL
    A6IJP7
    Conserved Domains (3) summary
    pfam16366
    Location:439 → 500
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:256 → 347
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:364 → 444
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108361.1: Suppressed sequence

    Description
    NM_001108361.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: CPEB2 (GeneID:132864).
Nucleotide Protein Strain
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