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Ankrd13a ankyrin repeat domain 13a [ Rattus norvegicus (Norway rat) ]

Gene ID: 360823, updated on 11-Apr-2024

Summary

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Official Symbol
Ankrd13aprovided by RGD
Official Full Name
ankyrin repeat domain 13aprovided by RGD
Primary source
RGD:1308577
See related
Ensembl:ENSRNOG00000001204 AllianceGenome:RGD:1308577
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ankrd13
Summary
Predicted to enable ubiquitin-dependent protein binding activity. Predicted to be involved in negative regulation of protein localization to endosome and negative regulation of receptor internalization. Predicted to be located in late endosome; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ANKRD13A (ankyrin repeat domain 13A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 262.8), Thymus (RPKM 228.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47458828..47488959, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41798196..41828327, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47558587..47588486, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA26 Neighboring gene similar to human chromosome 12 open reading frame 76 Neighboring gene GIT ArfGAP 2 Neighboring gene uncharacterized LOC102547088 Neighboring gene trichoplein, keratin filament binding

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Tanno H, et al. Mol Biol Cell, 2012 Apr. PMID 22298428, Free PMC Article
  2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-modified protein reader activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein localization to endosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 13A
Names
ankyrin repeat domain 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012148.1 → NP_001012148.1  ankyrin repeat domain-containing protein 13A

    See identical proteins and their annotated locations for NP_001012148.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085774
    UniProtKB/TrEMBL
    F7F6M4, Q5U313
    Related
    ENSRNOP00000001595.6, ENSRNOT00000001595.6
    Conserved Domains (4) summary
    cd00204
    Location:4 → 101
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11904
    Location:156 → 469
    GPCR_chapero_1; GPCR-chaperone
    pfam13637
    Location:41 → 90
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:40 → 71
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    47458828..47488959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249461.3 → XP_006249523.3  ankyrin repeat domain-containing protein 13A isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZL63
    Related
    ENSRNOP00000078565.1, ENSRNOT00000105521.1
    Conserved Domains (3) summary
    sd00045
    Location:151 → 182
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:267 → 581
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:124 → 207
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006249462.3 → XP_006249524.1  ankyrin repeat domain-containing protein 13A isoform X2

    UniProtKB/TrEMBL
    F7F6M4
    Conserved Domains (4) summary
    cd00204
    Location:12 → 88
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11904
    Location:143 → 457
    GPCR_chapero_1; GPCR-chaperone
    pfam13637
    Location:28 → 77
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:27 → 58
    ANK; ANK repeat [structural motif]

  3. XM_039089611.2 → XP_038945539.1  ankyrin repeat domain-containing protein 13A isoform X3

    UniProtKB/TrEMBL
    F7F6M4
    Conserved Domains (1) summary
    pfam11904
    Location:68 → 382
    GPCR_chapero_1; GPCR-chaperone

  4. XM_063271544.1 → XP_063127614.1  ankyrin repeat domain-containing protein 13A isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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