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Med15 mediator complex subunit 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360743, updated on 5-Mar-2024

Summary

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Official Symbol
Med15provided by RGD
Official Full Name
mediator complex subunit 15provided by RGD
Primary source
RGD:1307560
See related
Ensembl:ENSRNOG00000001877 AllianceGenome:RGD:1307560
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pcqap
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of mediator complex. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MED15 (mediator complex subunit 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 97.8), Spleen (RPKM 95.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96784974..96859635)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83280722..83356006)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87553868..87628631, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 22 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene ribosomal protein S15, pseudogene 13 Neighboring gene ribosomal protein L34, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil domain containing 74A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia. De Luca A, et al. Am J Med Genet B Neuropsychiatr Genet, 2003 Jan 1. PMID 12497610
  2. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
  3. Mediator and cohesin connect gene expression and chromatin architecture. Kagey MH, et al. Nature, 2010 Sep 23. PMID 20720539, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 15
Names
positive cofactor 2, multiprotein complex, glutamine/Q-rich-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108325.1 → NP_001101795.1  mediator of RNA polymerase II transcription subunit 15

    See identical proteins and their annotated locations for NP_001101795.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473999
    UniProtKB/TrEMBL
    A0A8I5ZVE0, A6JSK4, G3V684
    Related
    ENSRNOP00000002568.4, ENSRNOT00000002568.6
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 786
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    96784974..96859635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088530.2 → XP_038944458.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVE0
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 715
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  2. XM_006248702.5 → XP_006248764.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A373, A0A8I6GJV4
    Related
    ENSRNOP00000085424.1
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 746
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  3. XM_063270660.1 → XP_063126730.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

  4. XM_063270659.1 → XP_063126729.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

  5. XM_006248706.5 → XP_006248768.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZVE0
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 763
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  6. XM_039088531.2 → XP_038944459.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GJV4
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 703
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  7. XM_039088532.2 → XP_038944460.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZVE0
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 675
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  8. XM_039088533.2 → XP_038944461.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GJV4
    Conserved Domains (1) summary
    pfam09606
    Location:344 → 632
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
Nucleotide Protein Strain
Heading Accession and Version

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