Slc26a11 solute carrier family 26 member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc26a11provided by RGD
Official Full Name: solute carrier family 26 member 11provided by RGD
Primary source: RGD:1306178
See related: Ensembl:ENSRNOG00000030537 AllianceGenome:RGD:1306178
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable anion:anion antiporter activity and sulfate transmembrane transporter activity. Predicted to be involved in sulfate transport. Predicted to be located in several cellular components, including Golgi apparatus; lysosomal membrane; and nucleoplasm. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human SLC26A11 (solute carrier family 26 member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 50.9), Kidney (RPKM 42.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (105112020..105134393)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (104613498..104635873)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (108479105..108504188)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury.
Title: SLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury.
Results demonstrate that prolonged Na+ entry via either of two independent pathways (either VGSCs or NMDARs) converge to activate a Cl- influx pathway via SLC26A11 that is ultimately required for neuronal swelling and subsequent cell death.
Title: The cellular mechanisms of neuronal swelling underlying cytotoxic edema.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables chloride:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sulfate transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-independent sulfate anion transporter

Names: solute carrier family 26 (anion exchanger), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398807.1 → NP_001385736.1 sodium-independent sulfate anion transporter

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

F1M067

Related

ENSRNOP00000051870.3, ENSRNOT00000054987.3

Conserved Domains (1) summary

TIGR00815
Location:18 → 542

sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

105112020..105134393

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087534.1 → XP_038943462.1 sodium-independent sulfate anion transporter isoform X3

Conserved Domains (1) summary

TIGR00815
Location:18 → 451

sulP; high affinity sulphate transporter 1
XM_039087531.1 → XP_038943459.1 sodium-independent sulfate anion transporter isoform X1

UniProtKB/TrEMBL

F1M067

Conserved Domains (1) summary

TIGR00815
Location:18 → 542

sulP; high affinity sulphate transporter 1
XM_039087533.2 → XP_038943461.1 sodium-independent sulfate anion transporter isoform X2

Conserved Domains (1) summary

TIGR00815
Location:104 → 520

sulP; high affinity sulphate transporter 1
XM_039087532.2 → XP_038943460.1 sodium-independent sulfate anion transporter isoform X1

UniProtKB/TrEMBL

F1M067

Conserved Domains (1) summary

TIGR00815
Location:18 → 542

sulP; high affinity sulphate transporter 1
XM_039087535.1 → XP_038943463.1 sodium-independent sulfate anion transporter isoform X4

Conserved Domains (1) summary

COG0659
Location:101 → 428

SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]
XM_039087536.2 → XP_038943464.1 sodium-independent sulfate anion transporter isoform X5

Conserved Domains (1) summary

COG0659
Location:1 → 292

SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]