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Llgl2 LLGL scribble cell polarity complex component 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360661, updated on 11-Apr-2024

Summary

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Official Symbol
Llgl2provided by RGD
Official Full Name
LLGL scribble cell polarity complex component 2provided by RGD
Primary source
RGD:1560307
See related
Ensembl:ENSRNOG00000004834 AllianceGenome:RGD:1560307
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560307
Summary
Predicted to enable GTPase activator activity; PDZ domain binding activity; and myosin II binding activity. Predicted to be involved in several processes, including cytoskeleton organization; leucine transport; and regulation of Notch signaling pathway. Predicted to act upstream of or within establishment or maintenance of polarity of embryonic epithelium; labyrinthine layer development; and post-embryonic development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Orthologous to human LLGL2 (LLGL scribble cell polarity complex component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 109.5), Liver (RPKM 75.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Llgl2 in Genome Data Viewer
Location:
10q32.1
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101549911..101585466)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101050978..101086527)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104367826..104403726)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene cask-interacting protein 2 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene myosin XVB Neighboring gene RecQ like helicase 5 Neighboring gene small integral membrane protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LLGL2 rescues nutrient stress by promoting leucine uptake in ER(+) breast cancer. Saito Y, et al. Nature, 2019 May. PMID 30996345
  2. Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. Yasumi M, et al. J Biol Chem, 2005 Feb 25. PMID 15632202
  3. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Yamanaka T, et al. Curr Biol, 2003 Apr 29. PMID 12725730
  4. Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development. Sripathy S, et al. Mol Cell Biol, 2011 Jul. PMID 21606200, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-leucine transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment or maintenance of polarity of embryonic epithelium ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LLGL scribble cell polarity complex component 2
Names
LLGL2, scribble cell polarity complex component
lethal giant larvae homolog 2, scribble cell polarity complex component
lethal(2) giant larvae protein homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127549.1 → NP_001121021.1  LLGL scribble cell polarity complex component 2

    See identical proteins and their annotated locations for NP_001121021.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166481
    UniProtKB/TrEMBL
    A0A0G2JU05, B2GV09
    Related
    ENSRNOP00000090333.1, ENSRNOT00000107003.1
    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:36 → 72
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    101549911..101585466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247728.5 → XP_006247790.1  LLGL scribble cell polarity complex component 2 isoform X5

    See identical proteins and their annotated locations for XP_006247790.1

    UniProtKB/TrEMBL
    A0A0G2JU05, F7F3E6
    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:36 → 72
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

  2. XM_006247729.5 → XP_006247791.1  LLGL scribble cell polarity complex component 2 isoform X5

    See identical proteins and their annotated locations for XP_006247791.1

    UniProtKB/TrEMBL
    A0A0G2JU05, F7F3E6
    Related
    ENSRNOP00000006519.4
    Conserved Domains (3) summary
    COG2319
    Location:36 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:36 → 72
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:271 → 371
    LLGL; LLGL2

  3. XM_006247725.5 → XP_006247787.3  LLGL scribble cell polarity complex component 2 isoform X2

  4. XM_039086428.2 → XP_038942356.2  LLGL scribble cell polarity complex component 2 isoform X3

  5. XM_039086429.2 → XP_038942357.2  LLGL scribble cell polarity complex component 2 isoform X4

  6. XM_006247724.5 → XP_006247786.3  LLGL scribble cell polarity complex component 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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