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Grip71 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35130, updated on 4-Apr-2024

Summary

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Official Symbol
Grip71provided by FlyBase
Primary source
FLYBASE:FBgn0032705
Locus tag
Dmel_CG10346
See related
AllianceGenome:FB:FBgn0032705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10346; Dgp71WD; Dgrip71; Dmel\CG10346; Gp71WD; Grip71wd
Summary
Enables gamma-tubulin binding activity. Involved in microtubule cytoskeleton organization; mitotic cell cycle; and regulation of cell cycle. Located in cytoplasm; meiotic spindle midzone; and meiotic spindle pole. Part of gamma-tubulin large complex. Is expressed in organism. Orthologous to human NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
37A1-37A1; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18708846..18711297)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18708846..18711297)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Jwa Neighboring gene Fas-associated factor 2 Neighboring gene Inwardly rectifying potassium channel 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44768 Neighboring gene long non-coding RNA:CR44769

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. {gamma}-Tubulin ring complexes regulate microtubule plus end dynamics. Bouissou A, et al. J Cell Biol, 2009 Nov 2. PMID 19948476, Free PMC Article
  2. A novel microtubule nucleation pathway for meiotic spindle assembly in oocytes. Romé P, et al. J Cell Biol, 2018 Oct 1. PMID 30087124, Free PMC Article
  3. γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning. Bouissou A, et al. EMBO J, 2014 Jan 13. PMID 24421324, Free PMC Article
  4. A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes. Wainman A, et al. Genes Dev, 2009 Aug 15. PMID 19684111, Free PMC Article
  5. Characterization of a new gammaTuRC subunit with WD repeats. Gunawardane RN, et al. Mol Biol Cell, 2003 Mar. PMID 12631720, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in bicoid mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cell cycle HMP PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle assembly involved in female meiosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spindle assembly involved in female meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin ring complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in meiotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in meiotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pericentriolar material IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Grip71
Names
CG10346-PA
Grip71-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18708846..18711297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136058.5 → NP_609902.3  Grip71 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609902.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86LC4, Q9VJ57
    Conserved Domains (3) summary
    COG2319
    Location:92 → 302
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:78 → 114
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:57 → 302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86LC4 Q86LC4
Q8SZD0 Q8SZD0
Q9VJ57 Q9VJ57

Gene LinkOut

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