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apba2b amyloid beta (A4) precursor protein-binding, family A, member 2b [ Danio rerio (zebrafish) ]

Gene ID: 327160, updated on 27-Mar-2024

Summary

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Official Symbol
apba2bprovided by ZNC
Official Full Name
amyloid beta (A4) precursor protein-binding, family A, member 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5371
See related
Ensembl:ENSDARG00000060639 AllianceGenome:ZFIN:ZDB-GENE-030131-5371
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
apba2; fd15a04; wu:fd15a04
Summary
Predicted to enable amyloid-beta binding activity. Predicted to be involved in chemical synaptic transmission. Predicted to be located in synaptic vesicle. Predicted to be active in cytoplasm; dendritic spine; and plasma membrane. Orthologous to human APBA2 (amyloid beta precursor protein binding family A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (30787893..30915965)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (30516742..30644813)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) Neighboring gene methylmalonyl CoA epimerase Neighboring gene si:dkey-1h4.4 Neighboring gene sorbitol dehydrogenase Neighboring gene telomere repeat binding bouquet formation protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Recent assembly of an imprinted domain from non-imprinted components. Rapkins RW, et al. PLoS Genet, 2006 Oct. PMID 17069464, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
amyloid beta A4 precursor protein-binding family A member 2
Names
amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    30787893..30915965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168929.4 → XP_005168986.1  amyloid beta A4 precursor protein-binding family A member 2 isoform X1

    See identical proteins and their annotated locations for XP_005168986.1

    UniProtKB/TrEMBL
    A0A8M2BG86
    Conserved Domains (2) summary
    cd01208
    Location:447 → 620
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:746 → 817
    PDZ; PDZ domain (Also known as DHR or GLGF)

  2. XM_005168928.4 → XP_005168985.1  amyloid beta A4 precursor protein-binding family A member 2 isoform X1

    See identical proteins and their annotated locations for XP_005168985.1

    UniProtKB/TrEMBL
    A0A8M2BG86
    Conserved Domains (2) summary
    cd01208
    Location:447 → 620
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:746 → 817
    PDZ; PDZ domain (Also known as DHR or GLGF)

  3. XM_002662843.6 → XP_002662889.2  amyloid beta A4 precursor protein-binding family A member 2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5NS70, A0A8M1RKA4
    Related
    ENSDARP00000142680.1, ENSDART00000174000.2
    Conserved Domains (2) summary
    cd01208
    Location:447 → 619
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:745 → 816
    PDZ; PDZ domain (Also known as DHR or GLGF)

  4. XM_005168930.4 → XP_005168987.1  amyloid beta A4 precursor protein-binding family A member 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BGT9
    Related
    ENSDARP00000148950.1, ENSDART00000193106.1
    Conserved Domains (2) summary
    cd01208
    Location:447 → 608
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:734 → 805
    PDZ; PDZ domain (Also known as DHR or GLGF)

  5. XM_005168931.4 → XP_005168988.1  amyloid beta A4 precursor protein-binding family A member 2 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BG77, F1Q9E4
    Related
    ENSDARP00000080096.6, ENSDART00000085661.6
    Conserved Domains (2) summary
    cd01208
    Location:447 → 607
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:733 → 804
    PDZ; PDZ domain (Also known as DHR or GLGF)
Nucleotide Protein Strain
Heading Accession and Version

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