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stub1 STIP1 homology and U-Box containing protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 324243, updated on 14-Apr-2024

Summary

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Official Symbol
stub1provided by ZNC
Official Full Name
STIP1 homology and U-Box containing protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2963
See related
Ensembl:ENSDARG00000045228 AllianceGenome:ZFIN:ZDB-GENE-030131-2963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56076; wu:fc22f04
Summary
Predicted to enable several functions, including TPR domain binding activity; chaperone binding activity; and heat shock protein binding activity. Predicted to be involved in several processes, including cellular response to misfolded protein; positive regulation of cellular protein metabolic process; and proteolysis involved in cellular protein catabolic process. Predicted to act upstream of or within protein ubiquitination. Predicted to be active in Z disc. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (39656788..39668185)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (39768945..39780338)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 234 member A Neighboring gene uncharacterized LOC101885409 Neighboring gene LUC7-like (S. cerevisiae) Neighboring gene Ig kappa chain V-III region PC 7183-like Neighboring gene immunoglobulin kappa variable 1-9-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Chip Protein U-Box Domain Truncation Affects Purkinje Neuron Morphology and Leads to Behavioral Changes in Zebrafish. Pakdaman Y, et al. Front Mol Neurosci, 2021. PMID 34630034, Free PMC Article
  2. Structure and interactions of the helical and U-box domains of CHIP, the C terminus of HSP70 interacting protein. Xu Z, et al. Biochemistry, 2006 Apr 18. PMID 16605243
  3. Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes. Xu Z, et al. BMC Struct Biol, 2008 May 16. PMID 18485199, Free PMC Article
  4. Insights into the conformational dynamics of the E3 ubiquitin ligase CHIP in complex with chaperones and E2 enzymes. Graf C, et al. Biochemistry, 2010 Mar 16. PMID 20146531
  5. TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci. Davis EE, et al. Hum Mol Genet, 2020 Aug 11. PMID 32620954, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.
    Title: TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to misfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CHIP
Names
CHIP
NP_955968.2
XP_021325787.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199674.2 → NP_955968.2  E3 ubiquitin-protein ligase CHIP

    Status: VALIDATED

    Source sequence(s)
    CT573356, EH457730
    UniProtKB/TrEMBL
    A0A8M1PBP9, B2GQ87, F1Q8K3, F6NGW2, Q7ZTZ6
    Related
    ENSDARP00000118937.1, ENSDART00000145075.3
    Conserved Domains (4) summary
    pfam04564
    Location:211 → 283
    U-box; U-box domain
    sd00006
    Location:14 → 42
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:48 → 78
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:13 → 78
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    39656788..39668185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470112.1 → XP_021325787.1  E3 ubiquitin-protein ligase CHIP isoform X1

    UniProtKB/TrEMBL
    A0A8M9P5S7, B2GQ87, F6NGW2, Q7ZTZ6
    Conserved Domains (3) summary
    sd00006
    Location:14 → 42
    TPR; TPR repeat [structural motif]
    cd16654
    Location:215 → 281
    RING-Ubox_CHIP; U-box domain, a modified RING finger, found in carboxyl terminus of HSP70-interacting protein (CHIP) and similar proteins
    cl26005
    Location:14 → 191
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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