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ctsla cathepsin La [ Danio rerio (zebrafish) ]

Gene ID: 321453, updated on 27-Mar-2024

Summary

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Official Symbol
ctslaprovided by ZNC
Official Full Name
cathepsin Laprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-106
See related
Ensembl:ENSDARG00000007836 AllianceGenome:ZFIN:ZDB-GENE-030131-106
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ctsl1a; sb:cb143; hm:zeh1631; wu:fb70e06; wu:fi15c08; tdsubc_2f10; ik:tdsubc_2d2; xx:tdsubc_2d2; ik:tdsubc_2f10; xx:tdsubc_2f10
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in blood; gill; liver; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (44804775..44810915)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (44204647..44210762)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene growth arrest-specific 1a Neighboring gene death-associated protein kinase 1 Neighboring gene fructose-1,6-bisphosphatase 2 Neighboring gene fructose-1,6-bisphosphatase 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of Lactobacillus rhamnosus on zebrafish oocyte maturation: an FTIR imaging and biochemical analysis. Giorgini E, et al. Anal Bioanal Chem, 2010 Dec. PMID 20936269
  2. Molecular cloning and mRNA expression of the liver-specific cathepsin L1 gene of the olive flounder, Paralichthys olivaceus. Kim YO, et al. Biosci Biotechnol Biochem, 2011. PMID 21670505
  3. Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation. Lu PN, et al. JCI Insight, 2020 Oct 15. PMID 33055423, Free PMC Article
  4. The evolutionary legacy of size-selective harvesting extends from genes to populations. Uusi-Heikkilä S, et al. Evol Appl, 2015 Jul. PMID 26136825, Free PMC Article
  5. Inhibition of Embryonic HSP 90 Function Promotes Variation of Cold Tolerance in Zebrafish. Han B, et al. Front Genet, 2020. PMID 33343615, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ctsla is most likely the putative protease involved in yolk processing in zebrafish embryos.
    Title: Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cathepsin L1; cathepsin La
Names
cathepsin L, 1 a
cathepsin L, a
NP_997749.1
XP_005165325.1
XP_021331682.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212584.1 → NP_997749.1  cathepsin La precursor

    See identical proteins and their annotated locations for NP_997749.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066490
    UniProtKB/TrEMBL
    Q6NYR5
    Related
    ENSDARP00000157273.1, ENSDART00000184237.1
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:116 → 336
    Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    44804775..44810915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165268.2 → XP_005165325.1  cathepsin L1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCJ2
    Conserved Domains (2) summary
    smart00848
    Location:55 → 113
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:142 → 362
    Peptidase_C1; Papain family cysteine protease

  2. XM_021476007.1 → XP_021331682.1  cathepsin L1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PJP2, A5WVL6
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:116 → 336
    Peptidase_C1; Papain family cysteine protease
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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