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Kdm4B Lysine demethylase 4B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318918, updated on 4-Apr-2024

Summary

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Official Symbol
Kdm4Bprovided by FlyBase
Official Full Name
Lysine demethylase 4Bprovided by FlyBase
Primary source
FLYBASE:FBgn0053182
Locus tag
Dmel_CG33182
See related
AllianceGenome:FB:FBgn0053182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33182; CG4037; dJMJD2(2); dKdm4B; dKDM4B; Dmel\CG33182; kdm4b; Kdm4b; KDM4B
Summary
Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in nucleus. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including autistic disorder; gastrointestinal system cancer (multiple); head and neck cancer; malignant peripheral nerve sheath tumor; and withdrawal disorder. Orthologous to several human genes including KDM4A (lysine demethylase 4A) and KDM4C (lysine demethylase 4C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Kdm4B in Genome Data Viewer
Location:
49F4-49F7; 2-68 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13176553..13198337, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9064058..9085842, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene 1,4-Alpha-Glucan Branching Enzyme Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sequoia Neighboring gene Valyl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene Origin recognition complex subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster. Park SY, et al. J Korean Med Sci, 2019 Aug 26. PMID 31436053, Free PMC Article
  2. Stress and odorant receptor feedback during a critical period after hatching regulates olfactory sensory neuron differentiation in Drosophila. Jafari S, et al. PLoS Biol, 2021 Apr. PMID 33793547, Free PMC Article
  3. Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling. Tsurumi A, et al. Sci Rep, 2013 Oct 8. PMID 24100631, Free PMC Article
  4. Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9. Palomera-Sanchez Z, et al. J Biol Chem, 2010 Oct 8. PMID 20675387, Free PMC Article
  5. Characterization of Drosophila melanogaster JmjC+N histone demethylases. Lloret-Llinares M, et al. Nucleic Acids Res, 2008 May. PMID 18375980, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dmp53 enhances the expression of the dKDM4B histone demethylase, which demethylates H3K9me3 preferentially in heterochromatin regions. This mechanism appears to be essential for the proper function of the nucleotide excision repair system.
    Title: Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9.
  2. dKDM4B (CG33182) is a homolog of the histone H3K36 demethylase KDM4.
    Title: Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone H3K36 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K36 demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K36me2/H3K36me3 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K36me2/H3K36me3 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K9me2/H3K9me3 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9me2/H3K9me3 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lysine demethylase 4B
Names
CG33182-PA
CG33182-PB
CG33182-PC
CG33182-PD
CG33182-PE
Kdm4B-PA
Kdm4B-PB
Kdm4B-PC
Kdm4B-PD
Kdm4B-PE
histone demethylase 4B
lysine (K)-specific demethylase 4B
NP_001163137.1
NP_001163138.1
NP_001163139.1
NP_001260942.1
NP_788344.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13176553..13198337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274013.2 → NP_001260942.1  lysine demethylase 4B, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260942.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFJ8
    Conserved Domains (2) summary
    pfam02373
    Location:173 → 289
    JmjC; JmjC domain, hydroxylase
    pfam02375
    Location:11 → 44
    JmjN; jmjN domain

  2. NM_176164.4 → NP_788344.2  lysine demethylase 4B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788344.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V6L0
    UniProtKB/TrEMBL
    E1JH52, G4LU55
    Conserved Domains (2) summary
    pfam02373
    Location:173 → 289
    JmjC; JmjC domain, hydroxylase
    pfam02375
    Location:11 → 44
    JmjN; jmjN domain

  3. NM_001169668.2 → NP_001163139.1  lysine demethylase 4B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163139.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V6L0
    UniProtKB/TrEMBL
    E1JH52, G4LU55
    Conserved Domains (2) summary
    pfam02373
    Location:173 → 289
    JmjC; JmjC domain, hydroxylase
    pfam02375
    Location:11 → 44
    JmjN; jmjN domain

  4. NM_001169667.2 → NP_001163138.1  lysine demethylase 4B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163138.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V6L0
    UniProtKB/TrEMBL
    E1JH52, G4LU55
    Conserved Domains (2) summary
    pfam02373
    Location:173 → 289
    JmjC; JmjC domain, hydroxylase
    pfam02375
    Location:11 → 44
    JmjN; jmjN domain

  5. NM_001169666.2 → NP_001163137.1  lysine demethylase 4B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163137.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V6L0
    UniProtKB/TrEMBL
    E1JH52, G4LU55
    Conserved Domains (2) summary
    pfam02373
    Location:173 → 289
    JmjC; JmjC domain, hydroxylase
    pfam02375
    Location:11 → 44
    JmjN; jmjN domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFJ8 A0A0B4KFJ8
E1JH52 E1JH52
Q9V6L0.3 Q9V6L0

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