Gene description

thymidylate synthase

Locus Tag

ebA4415

Gene type

protein coding

RefSeq status

Reviewed

Organism

Aromatoleum aromaticum EbN1

Lineage

Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales; Rhodocyclaceae; Aromatoleum

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Names

thymidylate synthase

YP_159532.1

EC 2.1.1.45

ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

mRNA and Protein(s)

1. YP_159532.1 thymidylate synthase [Aromatoleum aromaticum EbN1]

   UniProtKB/Swiss-Prot

   Q5P233

   Conserved Domains (1) summary

   cd00351
   Location:3 – 217
   Blast Score: 797

   TS_Pyrimidine_HMase; Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...