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Armc8 armadillo repeat containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315949, updated on 3-Apr-2024

Summary

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Official Symbol
Armc8provided by RGD
Official Full Name
armadillo repeat containing 8provided by RGD
Primary source
RGD:1310477
See related
Ensembl:ENSRNOG00000014521 AllianceGenome:RGD:1310477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310477
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of GID complex and ubiquitin ligase complex. Orthologous to human ARMC8 (armadillo repeat containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 111.5), Heart (RPKM 97.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q31
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (108916274..109010877, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (100036946..100131544, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107723359..107819208, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480219 Neighboring gene muscle RAS oncogene homolog Neighboring gene NME/NM23 family member 9 Neighboring gene uncharacterized LOC120094240 Neighboring gene debranching RNA lariats 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. Kobayashi N, et al. Gene, 2007 Jul 15. PMID 17467196
  2. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
  3. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. Lampert F, et al. Elife, 2018 Jun 18. PMID 29911972, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
armadillo repeat-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173354.3 → NP_001166825.1  armadillo repeat-containing protein 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    B4F7A2, F1M943
    Related
    ENSRNOP00000019536.5, ENSRNOT00000019536.6
    Conserved Domains (4) summary
    COG5064
    Location:49 → 212
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:374 → 668
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:553 → 583
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:57 → 90
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    108916274..109010877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265591.1 → XP_063121661.1  armadillo repeat-containing protein 8 isoform X11

  2. XM_063265589.1 → XP_063121659.1  armadillo repeat-containing protein 8 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AI93

  3. XM_063265588.1 → XP_063121658.1  armadillo repeat-containing protein 8 isoform X7

  4. XM_063265592.1 → XP_063121662.1  armadillo repeat-containing protein 8 isoform X12

  5. XM_063265590.1 → XP_063121660.1  armadillo repeat-containing protein 8 isoform X10

    UniProtKB/TrEMBL
    A0A8I6GI95

  6. XM_006243625.5 → XP_006243687.1  armadillo repeat-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    B4F7A2
    Conserved Domains (4) summary
    COG5064
    Location:7 → 170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:332 → 626
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:511 → 541
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]

  7. XM_039081547.2 → XP_038937475.1  armadillo repeat-containing protein 8 isoform X9

    Conserved Domains (4) summary
    COG5064
    Location:15 → 346
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:272 → 475
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:184 → 223
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]

  8. XM_039081546.2 → XP_038937474.1  armadillo repeat-containing protein 8 isoform X6

    Conserved Domains (3) summary
    COG5064
    Location:7 → 170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:269 → 504
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]

  9. XM_006243624.5 → XP_006243686.2  armadillo repeat-containing protein 8 isoform X4

    UniProtKB/TrEMBL
    B4F7A2

  10. XM_039081545.2 → XP_038937473.1  armadillo repeat-containing protein 8 isoform X5

    UniProtKB/TrEMBL
    B4F7A2
    Conserved Domains (3) summary
    COG5064
    Location:7 → 170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:339 → 542
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]

  11. XM_006243623.5 → XP_006243685.2  armadillo repeat-containing protein 8 isoform X3

    UniProtKB/TrEMBL
    B4F7A2

  12. XM_039081544.2 → XP_038937472.1  armadillo repeat-containing protein 8 isoform X2

    UniProtKB/TrEMBL
    B4F7A2
    Conserved Domains (4) summary
    COG5064
    Location:7 → 170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:332 → 497
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:511 → 551
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]

  13. XM_006243622.5 → XP_006243684.2  armadillo repeat-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    B4F7A2
    Conserved Domains (4) summary
    COG5064
    Location:7 → 170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:332 → 626
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:511 → 541
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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