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Deup1 deuterosome assembly protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315438, updated on 3-Apr-2024

Summary

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Official Symbol
Deup1provided by RGD
Official Full Name
deuterosome assembly protein 1provided by RGD
Primary source
RGD:1306632
See related
Ensembl:ENSRNOG00000061247 AllianceGenome:RGD:1306632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc67; RGD1306632
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in centriole and deuterosome. Orthologous to human DEUP1 (deuterosome assembly protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 254.2) and Lung (RPKM 15.1) See more
Orthologs
human mouse all
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Genomic context

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Location:
8q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (20661687..20724083, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (12380300..12442649, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (14094742..14157232, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene V-type proton ATPase subunit G 1 pseudogene Neighboring gene uncharacterized LOC134479995 Neighboring gene single-pass membrane protein with coiled-coil domains 4 Neighboring gene uncharacterized LOC134479996 Neighboring gene solute carrier family 36 member 4 Neighboring gene melatonin receptor 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Zhao H, et al. Nat Cell Biol, 2013 Dec. PMID 24240477
  2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in multi-ciliated epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in multi-ciliated epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in deuterosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in deuterosome IEA
Inferred from Electronic Annotation
more info
  
located_in deuterosome ISO
Inferred from Sequence Orthology
more info
  
located_in deuterosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
deuterosome assembly protein 1
Names
coiled-coil domain containing 67
coiled-coil domain-containing protein 67
deuterosome protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014087.1 → NP_001014109.2  deuterosome assembly protein 1

    See identical proteins and their annotated locations for NP_001014109.2

    Status: VALIDATED

    Source sequence(s)
    BC085333
    UniProtKB/Swiss-Prot
    Q5U3Z6
    UniProtKB/TrEMBL
    A0A8L2R0S4
    Related
    ENSRNOP00000069511.2, ENSRNOT00000079034.2
    Conserved Domains (1) summary
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    20661687..20724083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265331.1 → XP_063121401.1  deuterosome assembly protein 1 isoform X4

  2. XM_008765933.4 → XP_008764155.1  deuterosome assembly protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008764155.1

    UniProtKB/TrEMBL
    A0A8L2R0S4, A0A8L2R4Y5
    Conserved Domains (2) summary
    COG1196
    Location:140 → 428
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  3. XM_063265330.1 → XP_063121400.1  deuterosome assembly protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5U3Z6

  4. XM_039081354.2 → XP_038937282.1  deuterosome assembly protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8L2R0S4
    Related
    ENSRNOP00000090446.1
    Conserved Domains (2) summary
    COG1196
    Location:123 → 437
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  5. XM_039081353.2 → XP_038937281.1  deuterosome assembly protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2R0S4, A0A8L2R4Y5
    Related
    ENSRNOP00000072022.2
    Conserved Domains (2) summary
    COG1196
    Location:140 → 428
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  6. XM_008765935.4 → XP_008764157.1  deuterosome assembly protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8L2R0S4
    Conserved Domains (1) summary
    pfam17045
    Location:1 → 258
    CEP63; Centrosomal protein of 63 kDa

  7. XM_063265332.1 → XP_063121402.1  deuterosome assembly protein 1 isoform X6

  8. XM_039081355.2 → XP_038937283.1  deuterosome assembly protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8L2R0S4
    Conserved Domains (2) summary
    COG1196
    Location:140 → 428
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  9. XM_039081356.2 → XP_038937284.1  deuterosome assembly protein 1 isoform X6

    Conserved Domains (2) summary
    COG1196
    Location:140 → 466
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  10. XM_039081359.2 → XP_038937287.1  deuterosome assembly protein 1 isoform X9

    Conserved Domains (2) summary
    COG1196
    Location:226 → 428
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  11. XM_063265333.1 → XP_063121403.1  deuterosome assembly protein 1 isoform X7

  12. XM_063265335.1 → XP_063121405.1  deuterosome assembly protein 1 isoform X8

  13. XM_039081358.2 → XP_038937286.1  deuterosome assembly protein 1 isoform X8

    Conserved Domains (2) summary
    COG1196
    Location:140 → 428
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  14. XM_039081360.2 → XP_038937288.1  deuterosome assembly protein 1 isoform X10

    Conserved Domains (2) summary
    COG1196
    Location:226 → 425
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U3Z6.2 GenPept UniProtKB/Swiss-Prot:Q5U3Z6

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