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Usp18 ubiquitin specific peptidase 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312688, updated on 13-Apr-2024

Summary

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Symbol
Usp18provided by RGD
Full Name
ubiquitin specific peptidase 18provided by RGD
Primary source
RGD:1359153
See related
Ensembl:ENSRNOG00000037198 AllianceGenome:RGD:1359153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ISG15-specific protease activity; cysteine-type endopeptidase activity; and thiol-dependent deubiquitinase. Predicted to be involved in negative regulation of type I interferon-mediated signaling pathway; protein deubiquitination; and regulation of inflammatory response. Predicted to act upstream of or within response to bacterium and response to stilbenoid. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP18 (ubiquitin specific peptidase 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 212.3), Spleen (RPKM 126.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q42
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (156143770..156171292)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154471634..154499154)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153812312..153834374)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 8 Neighboring gene uncharacterized LOC120102509 Neighboring gene uncharacterized LOC102553072 Neighboring gene solute carrier family 6 member 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy. Yuan L, et al. Neurosci Lett, 2023 Jul 27. PMID 37356565
  2. Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome. Meuwissen ME, et al. J Exp Med, 2016 Jun 27. PMID 27325888, Free PMC Article
  3. Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Kim KI, et al. Mol Cell Biol, 2006 Jan. PMID 16382139, Free PMC Article
  4. UBP43 (USP18) specifically removes ISG15 from conjugated proteins. Malakhov MP, et al. J Biol Chem, 2002 Mar 22. PMID 11788588
  5. Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. Murakawa M, et al. J Med Virol, 2017 Jul. PMID 28036111

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy.
    Title: USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ISG15-specific peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in response to stilbenoid ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubl carboxyl-terminal hydrolase 18
NP_001014080.1
XP_038963593.1
XP_038963594.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014058.2 → NP_001014080.1  ubl carboxyl-terminal hydrolase 18

    See identical proteins and their annotated locations for NP_001014080.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    F1LNS1, Q6AYC7
    Related
    ENSRNOP00000053020.3, ENSRNOT00000056174.5
    Conserved Domains (2) summary
    cd02257
    Location:53 → 358
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:52 → 357
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    156143770..156171292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107666.2 → XP_038963594.1  ubl carboxyl-terminal hydrolase 18 isoform X2

    UniProtKB/TrEMBL
    A6ILC0
    Conserved Domains (1) summary
    pfam00443
    Location:52 → 279
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. XM_039107665.1 → XP_038963593.1  ubl carboxyl-terminal hydrolase 18 isoform X1

    UniProtKB/TrEMBL
    A6ILC1
    Conserved Domains (1) summary
    cd02257
    Location:50 → 288
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
Nucleotide Protein Strain
Heading Accession and Version

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