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Ahcyl2 adenosylhomocysteinase-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312192, updated on 3-Apr-2024

Summary

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Official Symbol
Ahcyl2provided by RGD
Official Full Name
adenosylhomocysteinase-like 2provided by RGD
Primary source
RGD:1564895
See related
Ensembl:ENSRNOG00000039300 AllianceGenome:RGD:1564895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564895
Summary
Predicted to be involved in S-adenosylmethionine cycle. Predicted to be located in intracellular membrane-bounded organelle and neuron projection. Predicted to be active in cytosol. Orthologous to human AHCYL2 (adenosylhomocysteinase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 334.7), Adrenal (RPKM 280.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ahcyl2 in Genome Data Viewer
Location:
4q22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59348747..59498503)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (58381290..58531061)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57050241..57199870)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene smoothened, frizzled class receptor Neighboring gene uncharacterized LOC120102483 Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene striatin interacting protein 2 Neighboring gene phosphoglycerate kinase 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage. Ando H, et al. J Neurochem, 2009 Apr. PMID 19220705
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables adenosylhomocysteinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenosylhomocysteinase 3
Names
S-adenosylhomocysteine hydrolase-like 2
putative adenosylhomocysteinase 3
NP_001166981.2
XP_006236256.1
XP_008760993.1
XP_063142050.1
XP_063142051.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173510.2 → NP_001166981.2  adenosylhomocysteinase 3

    See identical proteins and their annotated locations for NP_001166981.2

    Status: VALIDATED

    Source sequence(s)
    BQ781566, CB713115, CV113234, FM059920, FN804654, JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IEE7, D3ZWL6
    Related
    ENSRNOP00000025165.8, ENSRNOT00000025165.8
    Conserved Domains (2) summary
    PRK05476
    Location:186 → 606
    PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
    pfam05221
    Location:186 → 611
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    59348747..59498503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762771.4 → XP_008760993.1  adenosylhomocysteinase 3 isoform X1

    See identical proteins and their annotated locations for XP_008760993.1

    UniProtKB/TrEMBL
    A0A8I6A7Z2, A0A8I6ABA9
    Related
    ENSRNOP00000091272.1
    Conserved Domains (1) summary
    smart00996
    Location:84 → 507
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

  2. XM_063285981.1 → XP_063142051.1  adenosylhomocysteinase 3 isoform X3

  3. XM_063285980.1 → XP_063142050.1  adenosylhomocysteinase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABA9

  4. XM_006236194.5 → XP_006236256.1  adenosylhomocysteinase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A7Z2
    Related
    ENSRNOP00000087181.1
    Conserved Domains (2) summary
    PRK05476
    Location:82 → 502
    PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
    pfam05221
    Location:82 → 507
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
Nucleotide Protein Strain
Heading Accession and Version

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