Irf2bp1 interferon regulatory factor 2 binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Irf2bp1provided by RGD
Official Full Name: interferon regulatory factor 2 binding protein 1provided by RGD
Primary source: RGD:1308312
See related: Ensembl:ENSRNOG00000014252 AllianceGenome:RGD:1308312
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable transcription corepressor activity and ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human IRF2BP1 (interferon regulatory factor 2 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (87780782..87783483)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78652736..78655437)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (79911516..79914217)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon regulatory factor 2-binding protein 1

NP_001100953.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107483.1 → NP_001100953.1 interferon regulatory factor 2-binding protein 1

See identical proteins and their annotated locations for NP_001100953.1

Status: PROVISIONAL

Source sequence(s)

CH473979

UniProtKB/TrEMBL

A6J8I8, D4AAZ8

Related

ENSRNOP00000019075.4, ENSRNOT00000019075.5

Conserved Domains (3) summary

PHA03247
Location:338 → 463

PHA03247; large tegument protein UL36; Provisional

cd16715
Location:501 → 556

vRING-HC_IRF2BP1; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 (IRF-2BP1)

pfam11261
Location:8 → 59

IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger