Carmil2 capping protein regulator and myosin 1 linker 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Carmil2provided by RGD
Official Full Name: capping protein regulator and myosin 1 linker 2provided by RGD
Primary source: RGD:1562390
See related: Ensembl:ENSRNOG00000024452 AllianceGenome:RGD:1562390
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rltpr; RGD1562390
Summary: Predicted to enable phospholipid binding activity. Predicted to be involved in several processes, including actin filament network formation; positive regulation of cellular component organization; and wound healing, spreading of cells. Predicted to act upstream of or within several processes, including T cell receptor signaling pathway; positive regulation of T cell activation; and positive regulation of cytokine production. Predicted to be located in several cellular components, including cytoskeleton; immunological synapse; and macropinosome. Predicted to be part of F-actin capping protein complex. Human ortholog(s) of this gene implicated in immunodeficiency 58. Orthologous to human CARMIL2 (capping protein regulator and myosin 1 linker 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 240.3), Spleen (RPKM 62.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50481911..50496672)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (33571255..33586783)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (37652383..37665333)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128404 (e-PCR)
- UniSTS:211712

RH132532 (e-PCR)
- UniSTS:215815

RH144673 (e-PCR)
- UniSTS:233918

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in actin filament network formation	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of monopolar cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in macropinosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: capping protein, Arp2/3 and myosin-I linker protein 2

Names: RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

50481911..50496672

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278651.1 → XP_063134721.1 capping protein, Arp2/3 and myosin-I linker protein 2 isoform X6
XM_063278650.1 → XP_063134720.1 capping protein, Arp2/3 and myosin-I linker protein 2 isoform X5
XM_063278652.1 → XP_063134722.1 capping protein, Arp2/3 and myosin-I linker protein 2 isoform X7
XM_063278648.1 → XP_063134718.1 capping protein, Arp2/3 and myosin-I linker protein 2 isoform X2

UniProtKB/TrEMBL

D3ZC15
XM_063278647.1 → XP_063134717.1 capping protein, Arp2/3 and myosin-I linker protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I6AF10
XM_063278649.1 → XP_063134719.1 capping protein, Arp2/3 and myosin-I linker protein 2 isoform X3
XM_039098220.2 → XP_038954148.1 capping protein, Arp2/3 and myosin-I linker protein 2 isoform X4

UniProtKB/TrEMBL

A0A8I6A9C8

Conserved Domains (5) summary

PHA03247
Location:812 → 1280

PHA03247; large tegument protein UL36; Provisional

sd00033
Location:335 → 368

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:105 → 129

LRR_AMN1; leucine-rich repeat [structural motif]

pfam16000
Location:665 → 954

CARMIL_C; CARMIL C-terminus

cl39015
Location:162 → 527

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...