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Drg1 developmentally regulated GTP binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305470, updated on 9-Mar-2024

Summary

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Official Symbol
Drg1provided by RGD
Official Full Name
developmentally regulated GTP binding protein 1provided by RGD
Primary source
RGD:1304993
See related
Ensembl:ENSRNOG00000018590 AllianceGenome:RGD:1304993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and potassium ion binding activity. Predicted to be involved in cytoplasmic translation; positive regulation of microtubule polymerization; and regulation of mitotic spindle assembly. Predicted to be located in cytosol and nuclear body. Predicted to be part of polysome. Predicted to be active in cytoplasm. Orthologous to human DRG1 (developmentally regulated GTP binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 239.5), Thymus (RPKM 200.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82328320..82344416, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78103876..78119976, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83460540..83476568, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481863 Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 1 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene LIM domain kinase 2 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics. Schellhaus AK, et al. Sci Rep, 2017 Aug 30. PMID 28855639, Free PMC Article
  2. Independent stabilizations of polysomal Drg1/Dfrp1 complex and non-polysomal Drg2/Dfrp2 complex in mammalian cells. Ishikawa K, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19819225
  3. Human Drg1 is a potassium-dependent GTPase enhanced by Lerepo4. Pérez-Arellano I, et al. FEBS J, 2013 Aug. PMID 23711155
  4. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Markolovic S, et al. Nat Chem Biol, 2018 Jul. PMID 29915238, Free PMC Article
  5. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94569

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables potassium ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
developmentally-regulated GTP-binding protein 1
NP_001009685.1
XP_038947931.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009685.1 → NP_001009685.1  developmentally-regulated GTP-binding protein 1

    See identical proteins and their annotated locations for NP_001009685.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088410
    UniProtKB/TrEMBL
    A0A8J8YRV3, F7ELI0, Q5I0F0
    Related
    ENSRNOP00000025241.5, ENSRNOT00000025241.6
    Conserved Domains (1) summary
    COG1163
    Location:1 → 367
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    82328320..82344416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092003.1 → XP_038947931.1  developmentally-regulated GTP-binding protein 1 isoform X1

    Conserved Domains (1) summary
    COG1163
    Location:1 → 195
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version

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