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Cdkl2 cyclin dependent kinase like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305242, updated on 13-Apr-2024

Summary

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Official Symbol
Cdkl2provided by RGD
Official Full Name
cyclin dependent kinase like 2provided by RGD
Primary source
RGD:1309625
See related
Ensembl:ENSRNOG00000002506 AllianceGenome:RGD:1309625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CDKL2 (cyclin dependent kinase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 93.9), Testes (RPKM 42.5) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (16312154..16347524)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (16027381..16063257)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17530170..17565950)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene G3BP stress granule assembly factor 2 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, pseudogene 1 Neighboring gene uncharacterized LOC120096578 Neighboring gene small Cajal body-specific RNA 23 like 2 Neighboring gene Sec61 translocon subunit gamma, pseudogene 2 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene THAP domain containing 6 Neighboring gene ring finger and CHY zinc finger domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
  2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase-like 2
Names
cyclin-dependent kinase-like 2 (CDC2-related kinase)
NP_001012035.2
XP_063129130.1
XP_063129131.1
XP_063129132.1
XP_063129133.1
XP_063129134.1
XP_063129135.1
XP_063129136.1
XP_063129137.1
XP_063129138.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012035.2 → NP_001012035.2  cyclin-dependent kinase-like 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6KKB1
    Related
    ENSRNOP00000073081.2, ENSRNOT00000079304.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    16312154..16347524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273060.1 → XP_063129130.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/TrEMBL
    A6KKB1

  2. XM_063273062.1 → XP_063129132.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/TrEMBL
    A6KKB1

  3. XM_063273066.1 → XP_063129136.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/TrEMBL
    A6KKB1

  4. XM_063273067.1 → XP_063129137.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/TrEMBL
    A6KKB1

  5. XM_063273061.1 → XP_063129131.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/TrEMBL
    A6KKB1

  6. XM_063273065.1 → XP_063129135.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/TrEMBL
    A6KKB1

  7. XM_063273063.1 → XP_063129133.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/TrEMBL
    A6KKB1

  8. XM_063273068.1 → XP_063129138.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/TrEMBL
    A6KKB1

  9. XM_063273064.1 → XP_063129134.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/TrEMBL
    A6KKB1

RNA

  1. XR_005492936.2 RNA Sequence

  2. XR_005492939.2 RNA Sequence

  3. XR_005492943.2 RNA Sequence

  4. XR_005492940.2 RNA Sequence

  5. XR_005492944.2 RNA Sequence

  6. XR_005492937.2 RNA Sequence

  7. XR_005492941.2 RNA Sequence

  8. XR_005492945.2 RNA Sequence

  9. XR_005492938.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIT0.1 GenPept UniProtKB/Swiss-Prot:Q5XIT0

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