U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Smurf2 SMAD specific E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303614, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Smurf2provided by RGD
Official Full Name
SMAD specific E3 ubiquitin protein ligase 2provided by RGD
Primary source
RGD:1310067
See related
Ensembl:ENSRNOG00000014623 AllianceGenome:RGD:1310067
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310067
Summary
Enables SMAD binding activity and transforming growth factor beta receptor binding activity. Predicted to be involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Predicted to be located in nuclear speck. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 231.8), Kidney (RPKM 110.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q32.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (92261516..92362185, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91761798..91862485, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (95018050..95118107, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microRNA 3064 Neighboring gene DEAD-box helicase 5 Neighboring gene centrosomal protein 95 Neighboring gene transfer RNA alanine (anticodon AGC) 91 Neighboring gene survival of motor neuron-related-splicing factor 30-like Neighboring gene uncharacterized LOC108352149

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Bone marrow mesenchymal stem cell-derived exosomes improve renal fibrosis via regulating Smurf 2/Smad 7. Liu Y, et al. Front Biosci (Landmark Ed), 2022 Jan 12. PMID 35090322
  2. MiR-568 mitigated cardiomyocytes apoptosis, oxidative stress response and cardiac dysfunction via targeting SMURF2 in heart failure rats. Zhang Q, et al. Heart Vessels, 2023 Jun. PMID 36717388
  3. The effects of miR-27a-3p-mediated Smurf2 on bleomycin A5-induced pulmonary fibrosis in rats. Zhang J, et al. Cell Mol Biol (Noisy-le-grand), 2020 Jun 5. PMID 32538751
  4. Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy. Xu Z, et al. Mol Med Rep, 2017 May. PMID 28447757, Free PMC Article
  5. Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43. Fykerud TA, et al. J Cell Sci, 2012 Sep 1. PMID 22623726

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-568 mitigated cardiomyocytes apoptosis, oxidative stress response and cardiac dysfunction via targeting SMURF2 in heart failure rats.
    Title: MiR-568 mitigated cardiomyocytes apoptosis, oxidative stress response and cardiac dysfunction via targeting SMURF2 in heart failure rats.
  2. Bone marrow mesenchymal stem cell-derived exosomes improve renal fibrosis via regulating Smurf 2/Smad 7.
    Title: Bone marrow mesenchymal stem cell-derived exosomes improve renal fibrosis via regulating Smurf 2/Smad 7.
  3. The effects of miR-27a-3p-mediated Smurf2 on bleomycin A5-induced pulmonary fibrosis in rats.
    Title: The effects of miR-27a-3p-mediated Smurf2 on bleomycin A5-induced pulmonary fibrosis in rats.
  4. MiR-411-3p alleviates Silica-induced pulmonary fibrosis by regulating Smurf2/TGF-beta signaling.
    Title: MiR-411-3p alleviates Silica-induced pulmonary fibrosis by regulating Smurf2/TGF-β signaling.
  5. By inhibition of Smurf2 translation, miR-322/503 induces EZH2 expression and activates Akt/GSK3beta pathway, thereby protecting cardiac myocytes from ischemia reperfusion injury.
    Title: Inhibition of Smurf2 translation by miR-322/503 protects from ischemia-reperfusion injury by modulating EZH2/Akt/GSK3β signaling.
  6. The effect of smurf2 on the degradation of SnoN by ubiquitination was found to be a key factor in diabetic nephropathy, which was mediated by the TGFbeta1/Smad signaling pathway.
    Title: Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy.
  7. These data identify Smurf2 as a novel regulator of connexin43 gap junctions.
    Title: Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43.
  8. Smurf2 interacts with Smad7 to suppress TGF-beta-mediated liver fibrosis through the ubiquitin-dependent degradation of TbetaRI during the early period of liver fibrosis.
    Title: Overexpression of Smad ubiquitin regulatory factor 2 suppresses transforming growth factor-β mediated liver fibrosis.
  9. Smurf2 siRNA did not influence the effects of TGF-beta(1) on the expression of Smad7/SnoN/Ski in airway remodeling.
    Title: Effects of Arkadia on airway remodeling through enhancing TGF-beta signaling in allergic rats.
  10. Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation.
    Title: Rheb and mTOR regulate neuronal polarity through Rap1B.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase SMURF2
NP_001100531.1
XP_038942099.1
XP_063125283.1
XP_063125285.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107061.3 → NP_001100531.1  E3 ubiquitin-protein ligase SMURF2

    See identical proteins and their annotated locations for NP_001100531.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5Y0P5, A6HK62, F1M3F2
    Related
    ENSRNOP00000019781.5, ENSRNOT00000019781.7
    Conserved Domains (5) summary
    cd08382
    Location:13 → 137
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:298 → 330
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:155 → 236
    PRP40; Splicing factor [RNA processing and modification]
    cd00078
    Location:393 → 745
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:159 → 188
    WW; WW domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    92261516..92362185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086171.2 → XP_038942099.1  E3 ubiquitin-protein ligase SMURF2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y0P5, A0A8I5ZUV2
    Related
    ENSRNOP00000082927.1
    Conserved Domains (5) summary
    cd08382
    Location:13 → 137
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:252 → 283
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:155 → 236
    PRP40; Splicing factor [RNA processing and modification]
    cd00078
    Location:340 → 692
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:159 → 188
    WW; WW domain

  2. XM_063269213.1 → XP_063125283.1  E3 ubiquitin-protein ligase SMURF2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A1F1

  3. XM_063269215.1 → XP_063125285.1  E3 ubiquitin-protein ligase SMURF2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous