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Klhl10 kelch-like family member 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303533, updated on 5-Mar-2024

Summary

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Official Symbol
Klhl10provided by RGD
Official Full Name
kelch-like family member 10provided by RGD
Primary source
RGD:1303290
See related
Ensembl:ENSRNOG00000016749 AllianceGenome:RGD:1303290
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within several processes, including homeostasis of number of cells within a tissue; male sex differentiation; and spermatid development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Orthologous to human KLHL10 (kelch like family member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 425.8) See more
Orthologs
human mouse all
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Genomic context

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Location:
10q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85876804..85893081)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85376442..85392720)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88356652..88372929)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase 10 Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene kelch-like family member 11 Neighboring gene ATP citrate lyase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. Yan W, et al. Proc Natl Acad Sci U S A, 2004 May 18. PMID 15136734, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94527

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male genitalia morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male gonad development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001510.1 → NP_001001510.1  kelch-like protein 10

    See identical proteins and their annotated locations for NP_001001510.1

    Status: PROVISIONAL

    Source sequence(s)
    AY495338
    UniProtKB/Swiss-Prot
    Q6JEL3
    UniProtKB/TrEMBL
    A6HJ35
    Related
    ENSRNOP00000022687.2, ENSRNOT00000022687.5
    Conserved Domains (2) summary
    PHA03098
    Location:36 → 572
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:329 → 372
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    85876804..85893081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6JEL3.1 GenPept UniProtKB/Swiss-Prot:Q6JEL3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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