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Zdhhc3 zinc finger DHHC-type palmitoyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301081, updated on 11-Apr-2024

Summary

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Official Symbol
Zdhhc3provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 3provided by RGD
Primary source
RGD:1309041
See related
Ensembl:ENSRNOG00000004344 AllianceGenome:RGD:1309041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including peptidyl-L-cysteine S-palmitoylation; positive regulation of GABAergic synaptic transmission; and protein localization to membrane. Predicted to act upstream of or within protein palmitoylation and protein targeting. Located in Golgi apparatus. Orthologous to human ZDHHC3 (zinc finger DHHC-type palmitoyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 179.8), Kidney (RPKM 108.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (131602663..131650998, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (122725206..122773542, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (132156216..132204484, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 1110059G10 Neighboring gene kinesin family member 15 Neighboring gene transmembrane protein 42 Neighboring gene transglutaminase 4 Neighboring gene exosome component 7 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene C-type lectin domain family 3, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. Fang C, et al. J Neurosci, 2006 Dec 6. PMID 17151279, Free PMC Article
  2. Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. Noritake J, et al. J Cell Biol, 2009 Jul 13. PMID 19596852, Free PMC Article
  3. Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain. Uemura T, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163046
  4. Oligomerization of DHHC protein S-acyltransferases. Lai J, et al. J Biol Chem, 2013 Aug 2. PMID 23793055, Free PMC Article
  5. Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells. Oh Y, et al. Cell Death Differ, 2012 Jul. PMID 22240897, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-stearoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in TRAIL-activated apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in TRAIL-activated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in lipoprotein localization to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoprotein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor localization to synapse ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC3
Names
acyltransferase ZDHHC3
zinc finger DHHC domain-containing protein 3
zinc finger, DHHC domain containing 3
zinc finger, DHHC-type containing 3
NP_001034103.1
NP_001400507.1
XP_038937239.1
XP_038937240.1
XP_038937241.1
XP_038937242.1
XP_038937243.1
XP_038937244.1
XP_038937245.1
XP_063121382.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039014.3 → NP_001034103.1  palmitoyltransferase ZDHHC3 isoform 2

    See identical proteins and their annotated locations for NP_001034103.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q2TGK3
    UniProtKB/TrEMBL
    A0A8I6GFS0
    Related
    ENSRNOP00000005817.5, ENSRNOT00000005817.7
    Conserved Domains (1) summary
    pfam01529
    Location:128 → 255
    DHHC; DHHC palmitoyltransferase

  2. NM_001413578.1 → NP_001400507.1  palmitoyltransferase ZDHHC3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K0R8
    Related
    ENSRNOP00000071556.2, ENSRNOT00000087427.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    131602663..131650998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081314.1 → XP_038937242.1  palmitoyltransferase ZDHHC3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZTB1
    Conserved Domains (1) summary
    pfam01529
    Location:128 → 253
    DHHC; DHHC palmitoyltransferase

  2. XM_039081311.1 → XP_038937239.1  palmitoyltransferase ZDHHC3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTB1
    Conserved Domains (1) summary
    pfam01529
    Location:128 → 253
    DHHC; DHHC palmitoyltransferase

  3. XM_039081312.2 → XP_038937240.1  palmitoyltransferase ZDHHC3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTB1
    Conserved Domains (1) summary
    pfam01529
    Location:128 → 253
    DHHC; DHHC palmitoyltransferase

  4. XM_039081313.2 → XP_038937241.1  palmitoyltransferase ZDHHC3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTB1
    Conserved Domains (1) summary
    pfam01529
    Location:128 → 253
    DHHC; DHHC palmitoyltransferase

  5. XM_039081315.2 → XP_038937243.1  palmitoyltransferase ZDHHC3 isoform X4

    Conserved Domains (1) summary
    pfam01529
    Location:1 → 101
    DHHC; DHHC palmitoyltransferase

  6. XM_039081316.2 → XP_038937244.1  palmitoyltransferase ZDHHC3 isoform X4

    Conserved Domains (1) summary
    pfam01529
    Location:1 → 101
    DHHC; DHHC palmitoyltransferase

  7. XM_039081317.2 → XP_038937245.1  palmitoyltransferase ZDHHC3 isoform X4

    Conserved Domains (1) summary
    pfam01529
    Location:1 → 101
    DHHC; DHHC palmitoyltransferase

  8. XM_063265312.1 → XP_063121382.1  palmitoyltransferase ZDHHC3 isoform X3

    UniProtKB/Swiss-Prot
    Q2TGK3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TGK3.1 GenPept UniProtKB/Swiss-Prot:Q2TGK3

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