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Ttll10 tubulin tyrosine ligase like 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298692, updated on 11-Apr-2024

Summary

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Official Symbol
Ttll10provided by RGD
Official Full Name
tubulin tyrosine ligase like 10provided by RGD
Primary source
RGD:1560839
See related
Ensembl:ENSRNOG00000020132 AllianceGenome:RGD:1560839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-glycine ligase activity, elongating. Predicted to be involved in protein polyglycylation. Predicted to be located in axoneme and microtubule cytoskeleton. Orthologous to human TTLL10 (tubulin tyrosine ligase like 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 226.3), Kidney (RPKM 47.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171912371..171937733, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166630147..166644114, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173471020..173517783, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 4 Neighboring gene TNF receptor superfamily member 18 Neighboring gene uncharacterized LOC106182250 Neighboring gene microRNA 3548 Neighboring gene microRNA 200a Neighboring gene microRNA 429 Neighboring gene microRNA 200b Neighboring gene similar to human chromosome 1 open reading frame 159 Neighboring gene ring finger protein 223

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Rogowski K, et al. Cell, 2009 Jun 12. PMID 19524510
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein-glycine ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-glycine ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-glycine ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-glycine ligase activity, elongating IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glycine ligase activity, elongating ISO
Inferred from Sequence Orthology
more info
  
enables protein-glycine ligase activity, elongating ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyglycylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein polyglycylase TTLL10
Names
tubulin tyrosine ligase-like family, member 10
tubulin--tyrosine ligase-like protein 10
NP_001019929.1
NP_001164004.1
XP_006239624.1
XP_063143579.1
XP_063143580.1
XP_063143581.1
XP_063143582.1
XP_063143583.1
XP_063143584.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024758.2 → NP_001019929.1  protein polyglycylase TTLL10 isoform 2

    See identical proteins and their annotated locations for NP_001019929.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BC097417, CK653520
    UniProtKB/TrEMBL
    A0A8L2QPH6
    Conserved Domains (1) summary
    cl17255
    Location:107 → 407
    ATP-grasp_4; ATP-grasp domain

  2. NM_001170533.1 → NP_001164004.1  protein polyglycylase TTLL10 isoform 1

    See identical proteins and their annotated locations for NP_001164004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC083833, BC097417, CK653520
    UniProtKB/TrEMBL
    A0A0H2UI23
    Related
    ENSRNOP00000063596.3, ENSRNOT00000064207.4
    Conserved Domains (1) summary
    cl17255
    Location:276 → 576
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171912371..171937733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287510.1 → XP_063143580.1  protein polyglycylase TTLL10 isoform X2

  2. XM_063287513.1 → XP_063143583.1  protein polyglycylase TTLL10 isoform X5

  3. XM_063287511.1 → XP_063143581.1  protein polyglycylase TTLL10 isoform X3

    UniProtKB/Swiss-Prot
    Q4V8F2, Q5XI57

  4. XM_063287512.1 → XP_063143582.1  protein polyglycylase TTLL10 isoform X4

  5. XM_063287509.1 → XP_063143579.1  protein polyglycylase TTLL10 isoform X1

  6. XM_063287514.1 → XP_063143584.1  protein polyglycylase TTLL10 isoform X7

  7. XM_006239562.5 → XP_006239624.1  protein polyglycylase TTLL10 isoform X6

    See identical proteins and their annotated locations for XP_006239624.1

    UniProtKB/TrEMBL
    A0A8L2QPH6
    Conserved Domains (1) summary
    cl17255
    Location:107 → 407
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI57.2 GenPept UniProtKB/Swiss-Prot:Q5XI57

Gene LinkOut

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