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Nmnat1 nicotinamide nucleotide adenylyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298653, updated on 5-Mar-2024

Summary

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Official Symbol
Nmnat1provided by RGD
Official Full Name
nicotinamide nucleotide adenylyltransferase 1provided by RGD
Primary source
RGD:1310996
See related
Ensembl:ENSRNOG00000015962 AllianceGenome:RGD:1310996
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; nicotinamide-nucleotide adenylyltransferase activity; and nicotinate-nucleotide adenylyltransferase activity. Involved in negative regulation of apoptotic DNA fragmentation; negative regulation of neuron apoptotic process; and positive regulation of MAPK cascade. Located in cytoplasm and nucleus. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 9 and spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis. Orthologous to human NMNAT1 (nicotinamide nucleotide adenylyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 38.3), Adrenal (RPKM 37.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (165193301..165211213, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (159910242..159928201, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (166409460..166430291, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquitination factor E4B Neighboring gene retinol binding protein 7 Neighboring gene uncharacterized LOC134479087 Neighboring gene leucine zipper and CTNNBIP1 domain containing Neighboring gene catenin, beta-interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nmnat 1: a Security Guard of Retinal Ganglion Cells (RGCs) in Response to High Glucose Stress. Zhou RM, et al. Cell Physiol Biochem, 2016. PMID 27184051
  2. Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s). Cohen MS, et al. Chem Biol, 2012 Feb 24. PMID 22365601, Free PMC Article
  3. The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy. Adalbert R, et al. Eur J Neurosci, 2006 Oct. PMID 17074042
  4. The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model. Beirowski B, et al. Eur J Neurosci, 2008 Sep. PMID 18783366
  5. Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase. Emanuelli M, et al. J Biol Chem, 2001 Jan 5. PMID 11027696

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nmnat1 protects Retinal Ganglion Cells against high glucose-induced injury via p38-MAPK signaling pathway.
    Title: Nmnat 1: a Security Guard of Retinal Ganglion Cells (RGCs) in Response to High Glucose Stress.
  2. The axonal pool of Wld(S) is necessary for protection from axon degeneration.
    Title: Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s).
  3. Data show that Wld(S) delays optic nerve (ON)axonal degeneration in experimental rat glaucoma for at least 2 weeks, especially in proximal ON where wild-type axons are most severely affected.
    Title: The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
  4. The slow Wallerian degeneration gene (Wld(S)) mutation delays Wallerian degeneration and axon pathology for several weeks in rats.
    Title: The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC156478

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nicotinamide-nucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinamide-nucleotide adenylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nicotinate-nucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate-nucleotide adenylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein ADP-ribosyltransferase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose ISO
Inferred from Sequence Orthology
more info
  
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within NAD biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NAD biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic DNA fragmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
Names
nicotinamide mononucleotide adenylyl transferase 1
NP_001032645.2
XP_006239491.1
XP_017448800.1
XP_038965628.1
XP_038965630.1
XP_038965632.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037556.2 → NP_001032645.2  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

    See identical proteins and their annotated locations for NP_001032645.2

    Status: PROVISIONAL

    Source sequence(s)
    BC127446
    UniProtKB/TrEMBL
    A0JPJ0, E9PSK8, Q32WF6
    Related
    ENSRNOP00000041982.5, ENSRNOT00000048914.5
    Conserved Domains (1) summary
    cd09286
    Location:9 → 255
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    165193301..165211213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109700.2 → XP_038965628.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ANE3
    Related
    ENSRNOP00000097390.1
    Conserved Domains (1) summary
    cd09286
    Location:36 → 282
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

  2. XM_039109704.2 → XP_038965632.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X5

    Conserved Domains (1) summary
    cl00015
    Location:40 → 139
    nt_trans; nucleotidyl transferase superfamily

  3. XM_006239429.5 → XP_006239491.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006239491.1

    UniProtKB/TrEMBL
    A0A8I5ZK56, A0A8I5ZV91
    Conserved Domains (1) summary
    cd09286
    Location:40 → 286
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

  4. XM_017593311.3 → XP_017448800.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X3

    UniProtKB/TrEMBL
    A0JPJ0, E9PSK8, Q32WF6
    Conserved Domains (1) summary
    cd09286
    Location:9 → 255
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

  5. XM_039109702.2 → XP_038965630.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X4

    Conserved Domains (1) summary
    cl00015
    Location:1 → 187
    nt_trans; nucleotidyl transferase superfamily
Nucleotide Protein Strain
Heading Accession and Version

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