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Ccn5 cellular communication network factor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29576, updated on 13-Apr-2024

Summary

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Official Symbol
Ccn5provided by RGD
Official Full Name
cellular communication network factor 5provided by RGD
Primary source
RGD:621867
See related
Ensembl:ENSRNOG00000010666 AllianceGenome:RGD:621867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wisp2
Summary
Enables integrin binding activity. Involved in negative regulation of cell population proliferation. Located in several cellular components, including cell surface; nucleus; and podosome. Orthologous to human CCN5 (cellular communication network factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 121.7), Heart (RPKM 61.9) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q42
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (172910670..172922064)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (152491247..152502639)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160207969..160219316)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101472 Neighboring gene uncharacterized LOC120101781 Neighboring gene uncharacterized LOC134486202 Neighboring gene potassium two pore domain channel subfamily K member 15 Neighboring gene regulating synaptic membrane exocytosis 4 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro. Ji X, et al. FASEB J, 2020 Apr. PMID 32058630
  2. Estrogen induces CCN5 expression in the rat uterus in vivo. Mason HR, et al. Endocrinology, 2004 Feb. PMID 14605002
  3. miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2. Zhang Y, et al. J Cell Sci, 2017 Mar 15. PMID 28167681
  4. The matricellular protein CCN5 regulates podosome function via interaction with integrin αvβ 3. Myers RB, et al. J Cell Commun Signal, 2014 Jun. PMID 24488697, Free PMC Article
  5. Copolymer-1 immunization reduces damage in retinal ganglion cells under high intraocular pressure through altering the expression of retinal neurotrophins. Yang B, et al. J Ocul Pharmacol Ther, 2010 Feb. PMID 20148653

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARgamma in vitro.
    Title: WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.
  2. miR-450a-5p promoted adipogenesis through repressing expression of WISP2 by targeting its 3' untranslated region.
    Title: miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2.
  3. COP-1 immunization might increase NT-3 expression by some unknown mechanism in high IOP rats and the change may be related to COP-1 therapeutic intervention.
    Title: Copolymer-1 immunization reduces damage in retinal ganglion cells under high intraocular pressure through altering the expression of retinal neurotrophins.
  4. data indicate that CCN5 protein is positively regulated by estrogen in the rat uterus and suggests that this gene may play an important role in maintaining normal uterine physiology
    Title: Estrogen induces CCN5 expression in the rat uterus in vivo.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CCN family member 5
Names
CCN family protein COP-1
CTGF-L
WISP-2
WNT1 inducible signaling pathway protein 2
connective tissue growth factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031590.2 → NP_113778.2  CCN family member 5 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q9JHC6
    UniProtKB/TrEMBL
    A6JX49, G3V7F3
    Related
    ENSRNOP00000014346.4, ENSRNOT00000014346.7
    Conserved Domains (3) summary
    cl17735
    Location:100 → 159
    VWC; von Willebrand factor type C domain
    pfam00219
    Location:26 → 78
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:194 → 237
    TSP1_CCN; CCN3 Nov like TSP1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    172910670..172922064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104504.1 → XP_038960432.1  CCN family member 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9JHC6
    UniProtKB/TrEMBL
    A6JX49, G3V7F3
    Conserved Domains (3) summary
    cl17735
    Location:100 → 159
    VWC; von Willebrand factor type C domain
    pfam00219
    Location:26 → 78
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:194 → 237
    TSP1_CCN; CCN3 Nov like TSP1 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHC6.1 GenPept UniProtKB/Swiss-Prot:Q9JHC6

Gene LinkOut

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