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Skic3 SKI3 subunit of superkiller complex [ Rattus norvegicus (Norway rat) ]

Gene ID: 294595, updated on 13-Apr-2024

Summary

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Official Symbol
Skic3provided by RGD
Official Full Name
SKI3 subunit of superkiller complexprovided by RGD
Primary source
RGD:1306062
See related
Ensembl:ENSRNOG00000040297 AllianceGenome:RGD:1306062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ttc37; RGD1306062
Summary
Predicted to be involved in nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'. Predicted to be located in cytosol; nucleoplasm; and transcriptionally active chromatin. Predicted to be part of Ski complex. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 1. Orthologous to human TTC37 (tetratricopeptide repeat domain 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 200.9), Spleen (RPKM 180.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q11
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (7363417..7526351)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (5631544..5783643)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (2891265..3037602)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 150 Neighboring gene arylsulfatase family, member K Neighboring gene small nucleolar RNA SNORA17 Neighboring gene family with sequence similarity 81, member B Neighboring gene EWS RNA-binding protein 2 Neighboring gene multiple C2 and transmembrane domain containing 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The human PAF complex coordinates transcription with events downstream of RNA synthesis. Zhu B, et al. Genes Dev, 2005 Jul 15. PMID 16024656, Free PMC Article
  2. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
  3. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ski complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ski complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
superkiller complex protein 3
Names
tetratricopeptide repeat domain 37
tetratricopeptide repeat protein 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427072.1 → NP_001414001.1  superkiller complex protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  2. NM_001427073.1 → NP_001414002.1  superkiller complex protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    7363417..7526351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281455.1 → XP_063137525.1  superkiller complex protein 3 isoform X1

  2. XM_063281449.1 → XP_063137519.1  superkiller complex protein 3 isoform X1

  3. XM_063281457.1 → XP_063137527.1  superkiller complex protein 3 isoform X3

  4. XM_063281450.1 → XP_063137520.1  superkiller complex protein 3 isoform X1

  5. XM_063281447.1 → XP_063137517.1  superkiller complex protein 3 isoform X1

  6. XM_063281448.1 → XP_063137518.1  superkiller complex protein 3 isoform X1

  7. XM_063281456.1 → XP_063137526.1  superkiller complex protein 3 isoform X2

  8. XM_063281451.1 → XP_063137521.1  superkiller complex protein 3 isoform X1

  9. XM_063281452.1 → XP_063137522.1  superkiller complex protein 3 isoform X1

  10. XM_063281454.1 → XP_063137524.1  superkiller complex protein 3 isoform X1

  11. XM_063281453.1 → XP_063137523.1  superkiller complex protein 3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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