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Klhl25 kelch-like family member 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293023, updated on 11-Apr-2024

Summary

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Official Symbol
Klhl25provided by RGD
Official Full Name
kelch-like family member 25provided by RGD
Primary source
RGD:1310815
See related
Ensembl:ENSRNOG00000010959 AllianceGenome:RGD:1310815
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310815
Summary
Predicted to be involved in protein ubiquitination; regulation of translational initiation; and ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL25 (kelch like family member 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 65.3), Kidney (RPKM 54.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (139134655..139159898)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (129724894..129750142)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (137333880..137359107, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485140 Neighboring gene biogenesis of ribosomes BRX1, pseudogene 1 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 69

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Translational homeostasis via the mRNA cap-binding protein, eIF4E. Yanagiya A, et al. Mol Cell, 2012 Jun 29. PMID 22578813, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116251

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 25
Names
ENC-2
ectoderm-neural cortex protein 2
kelch-like 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039006.1 → NP_001034095.1  kelch-like protein 25

    See identical proteins and their annotated locations for NP_001034095.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099111
    UniProtKB/Swiss-Prot
    Q4KLM4
    UniProtKB/TrEMBL
    A6JC16
    Related
    ENSRNOP00000097538.1, ENSRNOT00000111640.1
    Conserved Domains (3) summary
    PHA03098
    Location:39 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 374
    Kelch; KELCH repeat [structural motif]
    cd18254
    Location:24 → 151
    BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    139134655..139159898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759505.4 → XP_008757727.1  kelch-like protein 25 isoform X1

    See identical proteins and their annotated locations for XP_008757727.1

    UniProtKB/Swiss-Prot
    Q4KLM4
    UniProtKB/TrEMBL
    A6JC16
    Related
    ENSRNOP00000014553.3
    Conserved Domains (3) summary
    PHA03098
    Location:39 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 374
    Kelch; KELCH repeat [structural motif]
    cd18254
    Location:24 → 151
    BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

  2. XM_063284515.1 → XP_063140585.1  kelch-like protein 25 isoform X1

    UniProtKB/Swiss-Prot
    Q4KLM4
    UniProtKB/TrEMBL
    A6JC16

  3. XM_006229380.4 → XP_006229442.1  kelch-like protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006229442.1

    UniProtKB/Swiss-Prot
    Q4KLM4
    UniProtKB/TrEMBL
    A6JC16
    Related
    ENSRNOP00000091951.1
    Conserved Domains (3) summary
    PHA03098
    Location:39 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 374
    Kelch; KELCH repeat [structural motif]
    cd18254
    Location:24 → 151
    BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KLM4.1 GenPept UniProtKB/Swiss-Prot:Q4KLM4

Gene LinkOut

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