Cd36 CD36 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 29184, updated on 11-Apr-2024

Summary

Official Symbol: Cd36provided by RGD
Official Full Name: CD36 moleculeprovided by RGD
Primary source: RGD:2301
See related: Ensembl:ENSRNOG00000005906 AllianceGenome:RGD:2301
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fat; RGD1562323
Summary: Enables several functions, including oleic acid binding activity; scavenger receptor activity; and thrombospondin receptor activity. Involved in several processes, including fatty acid metabolic process; positive regulation of macromolecule metabolic process; and response to peptide hormone. Located in several cellular components, including brush border membrane; caveola; and sarcolemma. Part of protein-containing complex. Used to study interstitial lung disease (multiple); macular degeneration; myocardial infarction; obesity; and polycystic ovary syndrome. Biomarker of artery disease (multiple); hypertrophic cardiomyopathy; nephrosis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 5293.2), Spleen (RPKM 2488.5) and 6 other tissues See more
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Genomic context

Location:: 4q11

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (18209088..18302142)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (17317343..17410084)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (14150309..14191498)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis.
Title: Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis.
CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study.
Title: CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study.
Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage.
Title: Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage.
VR-10 polypeptide interacts with CD36 to induce cell apoptosis and autophagy in choroid-retinal endothelial cells: Identification of VR-10 as putative novel therapeutic agent for choroid neovascularization (CNV) treatment.
Title: VR-10 polypeptide interacts with CD36 to induce cell apoptosis and autophagy in choroid-retinal endothelial cells: Identification of VR-10 as putative novel therapeutic agent for choroid neovascularization (CNV) treatment.
High glucoseinduced upregulation of CD36 promotes inflammation stress via NFkappaB in H9c2 cells.
Title: High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells.
Effects of inflammatory response on renal function and TGF-beta1 pathway of rats with aging-related kidney damage by upregulating the expression of CD36.
Title: Effects of inflammatory response on renal function and TGF-β1 pathway of rats with aging-related kidney damage by upregulating the expression of CD36.
Cd36 gene expression in adipose and hepatic tissue mediates the lipids accumulation in liver of obese rats with sucrose-induced hepatic steatosis.
Title: Cd36 gene expression in adipose and hepatic tissue mediates the lipids accumulation in liver of obese rats with sucrose-induced hepatic steatosis.
miR-200b-3p targeted CD36 to regulate cardiocyte apoptosis of diabetic cardiomyopathy by activating PPAR-gamma signaling pathway.
Title: Microarray profiling analysis identifies the mechanism of miR-200b-3p/mRNA-CD36 affecting diabetic cardiomyopathy via peroxisome proliferator activated receptor-γ signaling pathway.
Hypertension, dyslipidemia, and insulin resistance in the spontaneously hypertensive rat can be alleviated by rescuing CD36 fatty acid translocase.
Title: Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36.
The M2000, as a novel NSAID is able to modify by lowering the gene expression levels of SR-A, LOX-1, CD36, and CD68 in treated rats compared to the untreated diabetic group, which may play an important role in preventing the complications that could lead to a cardioprotective efficacy.
Title: Cardioprotective effect of β-d-mannuronic acid (M2000) as a novel NSAID on gene expression of oxLDL scavenger receptors in the experimental diabetic model.

Submit: New GeneRIF Correction See all GeneRIFs (85)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Toll-like receptor binding	IEA Inferred from Electronic Annotation more info
enables Toll-like receptor binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	IEA Inferred from Electronic Annotation more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables high-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables lipoteichoic acid immune receptor activity	IEA Inferred from Electronic Annotation more info
enables lipoteichoic acid immune receptor activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor activity	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info
enables oleate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables oleate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oleic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidised low-density lipoprotein particle receptor activity	IEA Inferred from Electronic Annotation more info
enables oxidised low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info
enables scavenger receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables scavenger receptor activity	ISO Inferred from Sequence Orthology more info
enables short-chain fatty acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables short-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thrombospondin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transforming growth factor beta binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in amyloid fibril formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid-beta clearance by cellular catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance by cellular catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance by cellular catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid-beta clearance by cellular catabolic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic cell clearance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diacyl bacterial lipopeptide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diacyl bacterial lipopeptide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydroperoxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipoteichoic acid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to lipoteichoic acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cholesterol import	IEA Inferred from Electronic Annotation more info
involved_in cholesterol import	ISO Inferred from Sequence Orthology more info
involved_in cholesterol import	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IEA Inferred from Electronic Annotation more info
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in intestinal absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in intestinal cholesterol absorption	IEA Inferred from Electronic Annotation more info
involved_in intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info
involved_in intestinal cholesterol absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in lipid transport across blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoprotein transport	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into cell	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in low-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in maternal placenta development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide-cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in oxidised low-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in oxidised low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, recognition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phagocytosis, recognition	ISO Inferred from Sequence Orthology more info
involved_in plasma lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood microparticle formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood microparticle formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol storage	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of removal of superoxide radicals	IEA Inferred from Electronic Annotation more info
involved_in regulation of removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in regulation of toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to fatty acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to linoleic acid	IEA Inferred from Electronic Annotation more info
involved_in response to linoleic acid	ISO Inferred from Sequence Orthology more info
involved_in response to linoleic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipid	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to stilbenoid	IEA Inferred from Electronic Annotation more info
involved_in response to stilbenoid	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin B3	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of taste	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of taste	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of taste	ISS Inferred from Sequence or Structural Similarity more info
involved_in short-chain fatty acid transport	IEA Inferred from Electronic Annotation more info
involved_in short-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride transport	IEA Inferred from Electronic Annotation more info
involved_in triglyceride transport	ISO Inferred from Sequence Orthology more info
involved_in triglyceride transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IEA Inferred from Electronic Annotation more info
is_active_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: platelet glycoprotein 4

Names: CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); Cd36 antigen-like; GPIIIB; GPIV; PAS IV; PAS-4; adipocyte membrane protein; collagen type I receptor thrombospondin receptor; fatty acid translocase; fatty acid transport protein; glycoprotein IIIb; platelet glycoprotein IV

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031561.2 → NP_113749.2 platelet glycoprotein 4

See identical proteins and their annotated locations for NP_113749.2

Status: PROVISIONAL

Source sequence(s)

BC072543

UniProtKB/Swiss-Prot

Q07969, Q925W0

UniProtKB/TrEMBL

A0A096MJ39, A0A096MJJ0, F1LQ28, Q6IMX5

Related

ENSRNOP00000068147.2, ENSRNOT00000075962.3

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

18209088..18302142

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107196.2 → XP_038963124.1 platelet glycoprotein 4 isoform X1

UniProtKB/Swiss-Prot

Q07969, Q925W0

UniProtKB/TrEMBL

A0A096MJ39, A0A096MJJ0, F1LQ28, Q6IMX5

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
XM_039107194.2 → XP_038963122.1 platelet glycoprotein 4 isoform X1

UniProtKB/Swiss-Prot

Q07969, Q925W0

UniProtKB/TrEMBL

A0A096MJ39, A0A096MJJ0, F1LQ28, Q6IMX5

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
XM_063285673.1 → XP_063141743.1 platelet glycoprotein 4 isoform X1

UniProtKB/TrEMBL

A0A096MJJ0, F1LQ28, Q6IMX5
XM_039107190.2 → XP_038963118.1 platelet glycoprotein 4 isoform X1

UniProtKB/Swiss-Prot

Q07969, Q925W0

UniProtKB/TrEMBL

A0A096MJ39, A0A096MJJ0, F1LQ28, Q6IMX5

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
XM_039107192.2 → XP_038963120.1 platelet glycoprotein 4 isoform X1

UniProtKB/Swiss-Prot

Q07969, Q925W0

UniProtKB/TrEMBL

A0A096MJ39, A0A096MJJ0, F1LQ28, Q6IMX5

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
XM_063285672.1 → XP_063141742.1 platelet glycoprotein 4 isoform X1

UniProtKB/TrEMBL

A0A096MJJ0, F1LQ28, Q6IMX5
XM_063285674.1 → XP_063141744.1 platelet glycoprotein 4 isoform X1

UniProtKB/TrEMBL

A0A096MJJ0, F1LQ28, Q6IMX5
XM_063285677.1 → XP_063141747.1 platelet glycoprotein 4 isoform X1

UniProtKB/TrEMBL

A0A096MJJ0, F1LQ28, Q6IMX5
XM_063285675.1 → XP_063141745.1 platelet glycoprotein 4 isoform X1

UniProtKB/TrEMBL

A0A096MJJ0, F1LQ28, Q6IMX5
XM_039107195.2 → XP_038963123.1 platelet glycoprotein 4 isoform X1

UniProtKB/Swiss-Prot

Q07969, Q925W0

UniProtKB/TrEMBL

A0A096MJ39, A0A096MJJ0, F1LQ28, Q6IMX5

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
XM_063285671.1 → XP_063141741.1 platelet glycoprotein 4 isoform X1

UniProtKB/TrEMBL

A0A096MJJ0, F1LQ28, Q6IMX5
XM_039107191.2 → XP_038963119.1 platelet glycoprotein 4 isoform X1

UniProtKB/Swiss-Prot

Q07969, Q925W0

UniProtKB/TrEMBL

A0A096MJ39, A0A096MJJ0, F1LQ28, Q6IMX5

Conserved Domains (1) summary

pfam01130
Location:14 → 463

CD36; CD36 family
XM_063285676.1 → XP_063141746.1 platelet glycoprotein 4 isoform X1

UniProtKB/TrEMBL

A0A096MJJ0, F1LQ28, Q6IMX5
XM_063285670.1 → XP_063141740.1 platelet glycoprotein 4 isoform X1

UniProtKB/TrEMBL

A0A096MJJ0, F1LQ28, Q6IMX5