Vat1 vesicle amine transport 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vat1provided by RGD
Official Full Name: vesicle amine transport 1provided by RGD
Primary source: RGD:1308943
See related: Ensembl:ENSRNOG00000020684 AllianceGenome:RGD:1308943
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable oxidoreductase activity and zinc ion binding activity. Predicted to be involved in negative regulation of mitochondrial fusion. Located in mitochondrial outer membrane. Orthologous to human VAT1 (vesicle amine transport 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 291.6), Adrenal (RPKM 248.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86889793..86897411, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86389549..86397167, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89366898..89374516, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues.
Title: Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues.
We demonstrate that VAT-1 is a novel pathogenic factor in benign prostatic hyperplasia associated with cell proliferation.
Title: VAT-1 is a novel pathogenic factor of progressive benign prostatic hyperplasia.
Cloning of Mitofusin-binding protein.
Title: Identification of a novel protein that regulates mitochondrial fusion by modulating mitofusin (Mfn) protein function.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: synaptic vesicle membrane protein VAT-1 homolog

Names: mitofusin-binding protein; vesicle amine transport protein 1 homolog (T californica)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033683.2 → NP_001028855.1 synaptic vesicle membrane protein VAT-1 homolog

See identical proteins and their annotated locations for NP_001028855.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q3MIE4

Related

ENSRNOP00000028084.5, ENSRNOT00000028084.6

Conserved Domains (1) summary

cd08275
Location:60 → 398

MDR3; Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86889793..86897411 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085620.2 → XP_038941548.1 synaptic vesicle membrane protein VAT-1 homolog isoform X1

Conserved Domains (1) summary

cd08275
Location:39 → 295

MDR3; Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family
XM_039085621.2 → XP_038941549.1 synaptic vesicle membrane protein VAT-1 homolog isoform X2

Conserved Domains (1) summary

cd08275
Location:9 → 265

MDR3; Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family