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Smg8 SMG8 nonsense mediated mRNA decay factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 287596, updated on 13-Apr-2024

Summary

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Official Symbol
Smg8provided by RGD
Official Full Name
SMG8 nonsense mediated mRNA decay factorprovided by RGD
Primary source
RGD:1306862
See related
Ensembl:ENSRNOG00000005769 AllianceGenome:RGD:1306862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306862
Summary
Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of protein kinase activity. Orthologous to human SMG8 (SMG8 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 32.6), Spleen (RPKM 29.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q26
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72384012..72393746, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (71886742..71895776, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74379224..74388838, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene yippee-like 2 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 1 Neighboring gene interferon induced transmembrane protein 1, pseudogene 1 Neighboring gene uncharacterized LOC120095167 Neighboring gene proline rich 11 Neighboring gene microRNA 301a Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene tripartite motif-containing 37 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Yamashita A, et al. Genes Dev, 2009 May 1. PMID 19417104, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nonsense-mediated mRNA decay factor SMG8
Names
protein SMG8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398589.1 → NP_001385518.1  nonsense-mediated mRNA decay factor SMG8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D3ZQ80
    Related
    ENSRNOP00000008107.4, ENSRNOT00000008107.8
    Conserved Domains (1) summary
    pfam10220
    Location:42 → 985
    Smg8_Smg9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    72384012..72393746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_010055155.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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