CRHR1 corticotropin releasing hormone receptor 1 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: CRHR1provided by VGNC
Official Full Name: corticotropin releasing hormone receptor 1provided by VGNC
Primary source: VGNC:VGNC:57138
See related: BGD:BT15480; Ensembl:ENSBTAG00000002749
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CRFR1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (45791665..45843559)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
Title: Presence and distribution of urocortin and corticotrophin-releasing hormone receptors in the bovine thyroid gland.
CRHR1 and CRHR2 are expressed in the bovine adrenal gland.
Title: Expression of urocortin and corticotropin-releasing hormone receptors in the bovine adrenal gland.
results indicate that arginine vasopressin receptor V3 and corticotropin-releasing factor receptor 1 mRNAs are coordinately downregulated in the anterior pituitary during systemic inflammatory stress in cattle[AVP receptor V3]
Title: Bacterial lipopolysaccharide-induced coordinate downregulation of arginine vasopressin receptor V3 and corticotropin-releasing factor receptor 1 messenger ribonucleic acids in the anterior pituitary of endotoxemic steers.

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General gene information

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Markers

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497477

GDB:572888 (e-PCR)
- UniSTS:157778

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables corticotrophin-releasing factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables corticotropin-releasing hormone binding	IEA Inferred from Electronic Annotation more info	PubMed
enables corticotropin-releasing hormone receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: corticotropin-releasing factor receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174287.1 → NP_776712.1 corticotropin-releasing factor receptor 1 precursor

See identical proteins and their annotated locations for NP_776712.1

Status: PROVISIONAL

Source sequence(s)

AB055434

UniProtKB/TrEMBL

Q9BGU4

Related

ENSBTAP00000078548.1, ENSBTAT00000003567.6

Conserved Domains (2) summary

smart00008
Location:40 → 111

HormR; Domain present in hormone receptors

pfam00002
Location:116 → 359

7tm_2; 7 transmembrane receptor (Secretin family)