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MSR1 macrophage scavenger receptor 1 [ Bos taurus (cattle) ]

Gene ID: 281311, updated on 5-Mar-2024

Summary

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Official Symbol
MSR1provided by VGNC
Official Full Name
macrophage scavenger receptor 1provided by VGNC
Primary source
VGNC:VGNC:31704
See related
BGD:BT16011; Ensembl:ENSBTAG00000002885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 27
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (20909945..20990322)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 20 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene tumor suppressor candidate 3 Neighboring gene putative methyltransferase NSUN5C

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Rohrer L, et al. Nature, 1990 Feb 8. PMID 2300208
  2. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Kodama T, et al. Nature, 1990 Feb 8. PMID 2300204
  3. HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. Nakamura T, et al. Biochem Biophys Res Commun, 2002 Jan 18. PMID 11785981
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
macrophage scavenger receptor types I and II
Names
macrophage acetylated LDL receptor I and II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113240.1 → NP_001106711.1  macrophage scavenger receptor types I and II isoform 1

    See identical proteins and their annotated locations for NP_001106711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and protein isoform (1).
    Source sequence(s)
    AJ677598, AM037916, DY085614, X51689
    UniProtKB/Swiss-Prot
    A5PJV2, P21758
    UniProtKB/TrEMBL
    A0A3Q1NGM1
    Related
    ENSBTAP00000003751.4, ENSBTAT00000003751.5
    Conserved Domains (4) summary
    pfam01391
    Location:279 → 333
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:352 → 452
    SR; Scavenger receptor Cys-rich
    pfam03523
    Location:120 → 168
    Macscav_rec; Macrophage scavenger receptor
    cl25732
    Location:111 → 253
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_174113.2 → NP_776538.1  macrophage scavenger receptor types I and II isoform 2

    See identical proteins and their annotated locations for NP_776538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a distinct terminal exon resulting in a shorter protein isoform (2).
    Source sequence(s)
    AM018111, DY085614, X51689, X54183
    UniProtKB/Swiss-Prot
    P21758
    Related
    ENSBTAP00000003755.5, ENSBTAT00000003755.6
    Conserved Domains (3) summary
    pfam01391
    Location:279 → 333
    Collagen; Collagen triple helix repeat (20 copies)
    pfam03523
    Location:120 → 168
    Macscav_rec; Macrophage scavenger receptor
    cl25732
    Location:111 → 253
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    20909945..20990322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21758.1 GenPept UniProtKB/Swiss-Prot:P21758

Gene LinkOut

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