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GH1 growth hormone 1 [ Bos taurus (cattle) ]

Gene ID: 280804, updated on 16-Jan-2024

Summary

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Gene symbol
GH1
Gene description
growth hormone 1
See related
Ensembl:ENSBTAG00000017220
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GH
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Genomic context

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Location:
chromosome: 19
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (48117957..48119786, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 Neighboring gene testicular cell adhesion molecule 1 Neighboring gene CD79b molecule Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC132343099

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tracing Recombinant Bovine Somatotropin Ab(Use) Through Gene Expression in Blood, Hair Follicles, and Milk Somatic Cells: A Matrix Comparison. Lamas A, et al. Molecules, 2018 Jul 13. PMID 30011805, Free PMC Article
  2. A lncRNA promotes myoblast proliferation by up-regulating GH1. Yue Y, et al. In Vitro Cell Dev Biol Anim, 2017 Sep. PMID 28726188
  3. Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations. Benencia F, et al. Endocrinology, 2015 May. PMID 25521584, Free PMC Article
  4. Association between a polymorphism in intron 3 of the bovine growth hormone gene and growth traits in Holstein heifers in Antioquia. Arango J, et al. Genet Mol Res, 2014 Aug 15. PMID 25158245
  5. Increased milk protein synthesis in response to exogenous growth hormone is associated with changes in mechanistic (mammalian) target of rapamycin (mTOR)C1-dependent and independent cell signaling. Sciascia Q, et al. J Dairy Sci, 2013 Apr. PMID 23462168

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effect of miR-93 on GH secretion in pituitary cells of Yanbian yellow cattle.
    Title: The effect of miR-93 on GH secretion in pituitary cells of Yanbian yellow cattle.
  2. Exposure to growth hormone is associated with hepatic up-regulation of cPLA2alpha and COX.
    Title: Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX.
  3. Growth Hormone Reprograms Macrophages toward an Anti-Inflammatory and Reparative Profile in an MAFB-Dependent Manner.
    Title: Growth Hormone Reprograms Macrophages toward an Anti-Inflammatory and Reparative Profile in an MAFB-Dependent Manner.
  4. Tracing Recombinant Bovine Somatotropin Ab(Use) Through Gene Expression in Blood, Hair Follicles, and Milk Somatic Cells.
    Title: Tracing Recombinant Bovine Somatotropin Ab(Use) Through Gene Expression in Blood, Hair Follicles, and Milk Somatic Cells: A Matrix Comparison.
  5. A microarray analysis showed that lncYYW positively regulates the expression of growth hormone 1 and its downstream genes, AKT1 and PIK3CD, in bovine myoblasts. This discovery provides a good foundation for further study of the mechanism of action of lncYYW during bovine myoblast development
    Title: A lncRNA promotes myoblast proliferation by up-regulating GH1.
  6. bGH mice had increased body weight and decreased percent fat mass. Serum FGF21 levels were significantly elevated in bGH mice. Expression of Fgf21, Fgfr1, and Klb mRNA in white AT and liver were downregulated or unchanged in bGH mice.
    Title: Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice.
  7. GH/HpaII locus as candidate marker for body weight in cattle rather than MSTN/DraI.
    Title: Effect of Genetic Polymorphisms in GH/Hpa II and MSTN / Dra I Loci on Body Weight in Friesian Bull Calves.
  8. An SNP GH4.1 in a growth hormone gene was significantly related to a weaning weight.
    Title: Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle.
  9. The association of IGF1, GH, and PIT1 markers with growth and reproductive traits were assessed.
    Title: Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle.
  10. Male bovine GH transgenic mice have decreased adiposity, and have increased regulatory T cells and macrophages in mesenteric and subcutaneous white adipose tissue.
    Title: Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of growth IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
somatotropin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_180996.1 → NP_851339.1  somatotropin precursor

    See identical proteins and their annotated locations for NP_851339.1

    Status: PROVISIONAL

    Source sequence(s)
    M57764
    UniProtKB/Swiss-Prot
    A4GX96, P01246, Q28117, Q3LS73
    UniProtKB/TrEMBL
    B0FPG4, B0FPG6, I6WN98
    Related
    ENSBTAP00000022885.7, ENSBTAT00000022885.7
    Conserved Domains (1) summary
    cd10285
    Location:36 → 215
    somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    48117957..48119786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005220810.4 → XP_005220867.2  somatotropin isoform X1

    UniProtKB/TrEMBL
    B0FPG4
    Conserved Domains (1) summary
    cd10285
    Location:63 → 243
    somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01246.1 GenPept UniProtKB/Swiss-Prot:P01246

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Research Materials
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