Gene description

2-oxoglutarate dehydrogenase E1 component

Locus Tag

LIC12474

Gene type

protein coding

RefSeq status

Reviewed

Organism

Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130

Lineage

Bacteria; Spirochaetes; Spirochaetales; Leptospiraceae; Leptospira

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Names

2-oxoglutarate dehydrogenase E1 component

YP_002402.1

EC 1.2.4.2

SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

mRNA and Protein(s)

1. YP_002402.1 alpha-ketoglutarate decarboxylase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]

   UniProtKB/Swiss-Prot

   Q72PJ7

   Conserved Domains (3) summary

   cd02016
   Location:197 – 459
   Blast Score: 1177

   TPP_E1_OGDC_like; TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...

   PRK09404
   Location:9 – 918
   Blast Score: 3922

   kgd; alpha-ketoglutarate decarboxylase; Reviewed

   cl11410
   Location:578 – 771
   Blast Score: 446

   TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes.