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US11 tegument protein US11 [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703439, updated on 4-Dec-2023

Summary

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Gene symbol
US11
Gene description
tegument protein US11
Locus tag
HHV1gp00p03
Gene type
protein coding
RNA name
tegument protein US11
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001806.2 (144124..145495, complement)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene envelope glycoprotein J Neighboring gene envelope glycoprotein D Neighboring gene envelope glycoprotein I Neighboring gene envelope glycoprotein E Neighboring gene membrane protein US8A Neighboring gene membrane protein US9 Neighboring gene virion protein US10 Neighboring gene TAP transporter inhibitor ICP47 Neighboring gene transcriptional regulator ICP4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The US11 Gene of Herpes Simplex Virus 1 Promotes Neuroinvasion and Periocular Replication following Corneal Infection. Charron AJ, et al. J Virol, 2019 May 1. PMID 30760571, Free PMC Article
  2. Molecular anatomy of subcellular localization of HSV-1 tegument protein US11 in living cells. Xing J, et al. Virus Res, 2010 Oct. PMID 20633584, Free PMC Article
  3. Protection against heat and staurosporine mediated apoptosis by the HSV-1 US11 protein. Javouhey E, et al. Virology, 2008 Jun 20. PMID 18395766
  4. Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein. Sànchez R, et al. J Virol, 2007 Apr. PMID 17229694, Free PMC Article
  5. Binding of herpes simplex virus-1 US11 to specific RNA sequences. Bryant KF, et al. Nucleic Acids Res, 2005. PMID 16246910, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Discovery of a Novel Intron in US10/US11/US12 of HSV-1 Strain 17.
    Title: Discovery of a Novel Intron in US10/US11/US12 of HSV-1 Strain 17.
  2. Results demonstrate that the Us11 protein of HSV-1 spatially disrupts the TRIM23-TBK1 complex, which subsequently suppresses autophagy and autophagy-mediated virus restriction. Thus, expression of the Us11 protein facilitates HSV-1 replication. These data unveil new insight into viral escape from autophagy-mediated host restriction mechanisms.
    Title: Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy.
  3. the data indicate that US11 facilitates the countering of antiviral response of infected cells and promotes the efficient emergence of virus following reactivation.
    Title: The US11 Gene of Herpes Simplex Virus 1 Promotes Neuroinvasion and Periocular Replication following Corneal Infection.
  4. Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11
    Title: Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.
  5. Herpes simplex virus 1 Us11 suppresses host interferon beta1 production through the inhibition of the PACT.
    Title: Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein.
  6. Herpes simplex virus type 1 virion-derived US11 inhibits type 1 interferon-induced protein kinase R phosphorylation.
    Title: Herpes simplex virus type 1 virion-derived US11 inhibits type 1 interferon-induced protein kinase R phosphorylation.
  7. PKR expression and the PKR binding domain of herpes simplex virus 1 Us11 are required for the antiautophagic activity of Us11.
    Title: The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  8. HSV-1 US11 binds to RIG-I and MDA-5 and inhibits their downstream signaling pathway.
    Title: Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.
  9. found an increase in the nucleolar accumulation of US11 in nucleolin-depleted cells, thereby revealing that nucleolin could play a role in US11 nucleocytoplasmic trafficking through one-way directional transport out of the nucleolus
    Title: Nucleolin interacts with US11 protein of herpes simplex virus 1 and is involved in its trafficking.
  10. By constructing a series of deletion mutants fused with enhanced yellow fluorescent protein, three novel nucleolar localization signals of US11 were for the first time mapped to amino acids 84-125, 126-152, and 89-146, respectively.
    Title: Molecular anatomy of subcellular localization of HSV-1 tegument protein US11 in living cells.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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regulatory

  • Loc: c144145-144140 regulatory_class = polyA_signal_sequence
  • Loc: c145198-145193 regulatory_class = TATA_box
  • Loc: c145495-145490 regulatory_class = TATA_box

General protein information

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Preferred Names
tegument protein US11

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    144124..145495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137147.1 tegument protein US11 [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137147.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P04487
    UniProtKB/TrEMBL
    G8H9C4, G8HBI6
    Conserved Domains (1) summary
    PTZ00449
    Location:74 → 155
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
Nucleotide Protein
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