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hat1 histone acetyltransferase Hat1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542502, updated on 13-Mar-2024

Summary

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Gene symbol
hat1
Gene description
histone acetyltransferase Hat1
Primary source
PomBase:SPAC139.06
Locus tag
SPAC139.06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
kat1; SPAC23C4.01
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Genomic context

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Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003424.3 (1030125..1031941)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene L-saccharopine oxidase Neighboring gene miscRNA Neighboring gene putative succinate-semialdehyde dehydrogenase Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene coronin Crn1 Neighboring gene haspin-like kinase Hrk1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. Tong K, et al. Eukaryot Cell, 2012 Sep. PMID 22771823, Free PMC Article
  2. Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair. Benson LJ, et al. J Biol Chem, 2007 Jan 12. PMID 17052979
  3. A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice. Pai CC, et al. Nat Commun, 2014 Jun 9. PMID 24909977, Free PMC Article
  4. Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly. Subramanian L, et al. Open Biol, 2014 Apr 30. PMID 24789708, Free PMC Article
  5. Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex. Hayashi T, et al. Genes Cells, 2014 Jul. PMID 24774534

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hat1 associates with Mis16 and acetylates lysines 5 and 12 of histone H4. Deletion of Hat1 causes loss of silencing at telomeres.
    Title: Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.
  2. the role of Hat1 in DNA damage repair is evolutionarily conserved, the ability of H3 acetylation to compensate for Hat1 deletion appears to be more variable
    Title: Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4K12 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4K5 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4K8 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
histone acetyltransferase Hat1
NP_593173.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1030125..1031941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018570.2 → NP_593173.2  histone acetyltransferase Hat1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593173.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13922, Q9UTM7
    Conserved Domains (2) summary
    cd04301
    Location:171 → 223
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    pfam10394
    Location:7 → 149
    Hat1_N; Histone acetyl transferase HAT1 N-terminus
Nucleotide Protein
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