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spk1 MAP kinase Spk1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542474, updated on 15-Mar-2024

Summary

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Gene symbol
spk1
Gene description
MAP kinase Spk1
Locus tag
SPAC31G5.09c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2999546..3001687, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene putative protein Rgg8 Neighboring gene tetraspan protein Dni1 Neighboring gene uroporphyrinogen-III synthase Ups1 Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene Myb family protein Eta2 Neighboring gene miscRNA Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of the pheromone-responsive MAP kinase drives haploid cells to undergo ectopic meiosis with normal telomere clustering and sister chromatid segregation in fission yeast. Yamamoto TG, et al. J Cell Sci, 2004 Aug 1. PMID 15265989
  2. A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans. Halova L, et al. Open Biol, 2021 Apr. PMID 33823663, Free PMC Article
  3. Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase. Gotoh Y, et al. Mol Cell Biol, 1993 Oct. PMID 8413241, Free PMC Article
  4. Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase Byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe. Henkel J, et al. Differentiation, 2001 Jun. PMID 11683500
  5. Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression. Yabana N, et al. Mol Cell Biol, 1996 Jul. PMID 8668157, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. activation of Spk1 drives meiosis in S. pombe
    Title: Activation of the pheromone-responsive MAP kinase drives haploid cells to undergo ectopic meiosis with normal telomere clustering and sister chromatid segregation in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

polyA_site

  • Loc: c2999546
  • Loc: c2999663

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables MAP kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pheromone response MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MAP kinase Spk1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2999546..3001687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019435.2 → NP_594009.1  MAP kinase Spk1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594009.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P27638
    Conserved Domains (2) summary
    smart00220
    Location:39 → 327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07849
    Location:33 → 371
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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