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ned8 ubiquitin-like protein modifier Ned8 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540129, updated on 15-Mar-2024

Summary

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Gene symbol
ned8
Gene description
ubiquitin-like protein modifier Ned8
Primary source
PomBase:SPBC12D12.08c
Locus tag
SPBC12D12.08c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
nedd8; SPBC24C6.01c; ubl1
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Genomic context

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See ned8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003423.3 (2319758..2320292, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene cyclin CycC-like Srb mediator subunit Srb11 Neighboring gene thioredoxin Trx2 Neighboring gene tRNA-Pro Neighboring gene miscRNA Neighboring gene putative ATP-dependent RNA helicase Spb4 Neighboring gene putative proline--tRNA (Pro) ligase Neighboring gene 5S ribosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast. Osaka F, et al. EMBO J, 2000 Jul 3. PMID 10880460, Free PMC Article
  2. But1 and But2 proteins bind to Uba3, a catalytic subunit of E1 for neddylation, in fission yeast. Yashiroda H, et al. Biochem Biophys Res Commun, 2003 Nov 21. PMID 14623327
  3. The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. Zhou C, et al. BMC Biochem, 2001. PMID 11504566, Free PMC Article
  4. Nedd8 processing enzymes in Schizosaccharomyces pombe. O'Donoghue JE, et al. BMC Biochem, 2013 Mar 15. PMID 23496905, Free PMC Article
  5. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Geyer R, et al. Mol Cell, 2003 Sep. PMID 14527422

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tag activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein neddylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-like protein modifier Ned8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2319758..2320292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021864.2 → NP_595955.1  ubiquitin-like protein modifier Ned8 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595955.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14399
    Conserved Domains (2) summary
    cd01806
    Location:1 → 76
    Nedd8; Nebb8-like ubiquitin protein
    smart00213
    Location:1 → 72
    UBQ; Ubiquitin homologues
Nucleotide Protein
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