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sup35 eRF3-like class 2 translation release factor sup35 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539479, updated on 13-Mar-2024

Summary

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Gene symbol
sup35
Gene description
eRF3-like class 2 translation release factor sup35
Primary source
PomBase:SPCC584.04
Locus tag
SPCC584.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
erf3
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Genomic context

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Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (1535396..1538011)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene putative sulfite reductase NADPH flavoprotein subunit Neighboring gene putative Ran GTP-binding protein Neighboring gene putative Cu metalloregulatory transcription factor Cuf2 Neighboring gene putative SNARE-binding protein Sec1 Neighboring gene single-stranded DNA-binding protein Ssb2 Neighboring gene G-protein-coupled receptor Git3 Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe. Kong C, et al. Mol Cell, 2004 Apr 23. PMID 15099522
  2. Nonsense codon suppression in fission yeast due to mutations of tRNA(Ser.11) and translation release factor Sup35 (eRF3). Protacio RU, et al. Curr Genet, 2015 May. PMID 25519804, Free PMC Article
  3. The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion. Sénéchal P, et al. PLoS One, 2009 Sep 11. PMID 19759825, Free PMC Article
  4. The stretch of C-terminal acidic amino acids of translational release factor eRF1 is a primary binding site for eRF3 of fission yeast. Ito K, et al. RNA, 1998 Aug. PMID 9701287, Free PMC Article
  5. Structure of the Dom34-Hbs1 complex and implications for no-go decay. Chen L, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20890290

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we localized another suppressor gene to the sup35 locus and we determined that the mechanism of suppression involves an amino acid substitution in a GTP elongation factor Tu domain of the ubiquitous eukaryotic translation release factor 3 (eRF3).
    Title: Nonsense codon suppression in fission yeast due to mutations of tRNA(Ser.11) and translation release factor Sup35 (eRF3).
  2. Hsp104 disaggregase is unable to propagate the [PSI] prion
    Title: The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion.
  3. eRF1's M domain contacts eRF3's GTPase domain
    Title: Structural insights into eRF3 and stop codon recognition by eRF1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation release factor activity EXP
Inferred from Experiment
more info
 PubMed 
contributes_to translation release factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translational termination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of translation release factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of translation release factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
eRF3-like class 2 translation release factor sup35

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1535396..1538011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023215.2 → NP_588225.1  eRF3-like class 2 translation release factor sup35 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588225.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74718, P78857
    Conserved Domains (4) summary
    cd01883
    Location:240 → 462
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:236 → 662
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    cd03698
    Location:468 → 549
    eRF3_II_like; Domain II of the eukaryotic class II release factor-like proteins
    cd03704
    Location:555 → 660
    eRF3_C_III; C-terminal domain of eRF3
Nucleotide Protein
Heading Accession and Version

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