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Dock4 dedicator of cytokinesis 4 [ Mus musculus (house mouse) ]

Gene ID: 238130, updated on 11-Apr-2024

Summary

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Official Symbol
Dock4provided by MGI
Official Full Name
dedicator of cytokinesis 4provided by MGI
Primary source
MGI:MGI:1918006
See related
Ensembl:ENSMUSG00000035954 AllianceGenome:MGI:1918006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0716; 5330406C03; C030023J22; 6330411N01Rik
Summary
Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in cell chemotaxis; negative regulation of vascular associated smooth muscle contraction; and positive regulation of vascular associated smooth muscle cell migration. Located in stereocilium. Is expressed in dorsal aorta; ovary; and testis. Orthologous to human DOCK4 (dedicator of cytokinesis 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 9.4), lung adult (RPKM 8.7) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 B1; 12 18.06 cM
Exon count:
53
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40495956..40896873)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40445957..40846874)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31954 Neighboring gene STARR-positive B cell enhancer mm9_chr12:40983751-40984051 Neighboring gene STARR-seq mESC enhancer starr_31955 Neighboring gene predicted gene, 40403 Neighboring gene STARR-seq mESC enhancer starr_31956 Neighboring gene zinc finger protein 277 Neighboring gene STARR-seq mESC enhancer starr_31957 Neighboring gene STARR-seq mESC enhancer starr_31958 Neighboring gene STARR-positive B cell enhancer mm9_chr12:41172293-41172594 Neighboring gene predicted gene, 40406 Neighboring gene STARR-seq mESC enhancer starr_31959 Neighboring gene STARR-seq mESC enhancer starr_31960 Neighboring gene STARR-seq mESC enhancer starr_31961 Neighboring gene STARR-seq mESC enhancer starr_31962 Neighboring gene STARR-seq mESC enhancer starr_31963 Neighboring gene STARR-seq mESC enhancer starr_31965 Neighboring gene STARR-seq mESC enhancer starr_31966 Neighboring gene predicted gene, 19441 Neighboring gene SET translocation pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age. Guo D, et al. Cell Mol Neurobiol, 2023 Apr. PMID 35635601
  2. DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function. Yazbeck P, et al. Arterioscler Thromb Vasc Biol, 2022 Jul. PMID 35477279, Free PMC Article
  3. Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice. Yang X, et al. Behav Brain Res, 2021 May 21. PMID 33705839
  4. Two Autism/Dyslexia Linked Variations of DOCK4 Disrupt the Gene Function on Rac1/Rap1 Activation, Neurite Outgrowth, and Synapse Development. Huang M, et al. Front Cell Neurosci, 2019. PMID 32009906, Free PMC Article
  5. Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. Guo D, et al. Mol Psychiatry, 2021 May. PMID 31388105, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age.
    Title: Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age.
  2. DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function.
    Title: DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function.
  3. DOCK4 regulates ghrelin production in gastric X/A-like cells.
    Title: DOCK4 regulates ghrelin production in gastric X/A-like cells.
  4. Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice.
    Title: Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice.
  5. DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.
    Title: DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.
  6. Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function.
    Title: Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function.
  7. SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
    Title: SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.
  8. Dock4 binds to SH3YL1 through the C-terminal proline-rich region.
    Title: Dock4 forms a complex with SH3YL1 and regulates cancer cell migration.
  9. The Atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.
    Title: The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.
  10. Rac-DOCK4-actin-binding protein harmonin-activated signaling pathway is possibly involved in regulating actin cytoskeleton organization in stereocilia of the inner ear.
    Title: An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular associated smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in stereocilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stereocilium bundle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dedicator of cytokinesis protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172803.2 → NP_766391.2  dedicator of cytokinesis protein 4

    See identical proteins and their annotated locations for NP_766391.2

    Status: VALIDATED

    Source sequence(s)
    AK122353, BB641326, CAAA01013241
    Consensus CDS
    CCDS25895.1
    UniProtKB/Swiss-Prot
    B2RUG6, P59764
    Related
    ENSMUSP00000047387.7, ENSMUST00000037488.8
    Conserved Domains (4) summary
    cd08695
    Location:400 → 584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:1206 → 1596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:10 → 65
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69 → 392
    DOCK_N; DOCK N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    40495956..40896873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515085.3 → XP_006515148.1  dedicator of cytokinesis protein 4 isoform X1

    Conserved Domains (5) summary
    cd08695
    Location:400 → 584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:1206 → 1596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:10 → 65
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam03154
    Location:1731 → 1937
    Atrophin-1; Atrophin-1 family
    pfam16172
    Location:69 → 392
    DOCK_N; DOCK N-terminus

  2. XM_006515089.3 → XP_006515152.1  dedicator of cytokinesis protein 4 isoform X6

    Conserved Domains (4) summary
    cd08695
    Location:400 → 584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:1206 → 1596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:10 → 65
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69 → 392
    DOCK_N; DOCK N-terminus

  3. XM_006515090.3 → XP_006515153.1  dedicator of cytokinesis protein 4 isoform X7

    UniProtKB/TrEMBL
    A0A1Y7VLY2
    Related
    ENSMUSP00000152420.2, ENSMUST00000220912.2
    Conserved Domains (4) summary
    cd08695
    Location:400 → 584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:1206 → 1596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:10 → 65
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69 → 392
    DOCK_N; DOCK N-terminus

  4. XM_006515088.3 → XP_006515151.1  dedicator of cytokinesis protein 4 isoform X4

    Conserved Domains (4) summary
    cd08695
    Location:400 → 584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:1206 → 1596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:10 → 65
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69 → 392
    DOCK_N; DOCK N-terminus

  5. XM_030246698.1 → XP_030102558.1  dedicator of cytokinesis protein 4 isoform X5

    Conserved Domains (5) summary
    cd08695
    Location:400 → 584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:1206 → 1596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:10 → 65
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam06484
    Location:1701 → 1832
    Ten_N; Teneurin Intracellular Region
    pfam16172
    Location:69 → 392
    DOCK_N; DOCK N-terminus

  6. XM_017315054.2 → XP_017170543.1  dedicator of cytokinesis protein 4 isoform X9

    Conserved Domains (4) summary
    cd08695
    Location:400 → 584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:1206 → 1596
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:10 → 65
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69 → 392
    DOCK_N; DOCK N-terminus

  7. XM_006515086.3 → XP_006515149.1  dedicator of cytokinesis protein 4 isoform X2

    Conserved Domains (5) summary
    cd08695
    Location:400 → 584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:1197 → 1587
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:10 → 65
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam03154
    Location:1722 → 1928
    Atrophin-1; Atrophin-1 family
    pfam16172
    Location:69 → 392
    DOCK_N; DOCK N-terminus

  8. XM_006515087.3 → XP_006515150.1  dedicator of cytokinesis protein 4 isoform X3

    Conserved Domains (5) summary
    cd08695
    Location:400 → 584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:1197 → 1587
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:10 → 65
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam06484
    Location:1710 → 1841
    Ten_N; Teneurin Intracellular Region
    pfam16172
    Location:69 → 392
    DOCK_N; DOCK N-terminus

  9. XM_036157392.1 → XP_036013285.1  dedicator of cytokinesis protein 4 isoform X8

    Conserved Domains (4) summary
    cd08695
    Location:400 → 584
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11705
    Location:1197 → 1587
    DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
    cd12049
    Location:10 → 65
    SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
    pfam16172
    Location:69 → 392
    DOCK_N; DOCK N-terminus

RNA

  1. XR_004937494.1 RNA Sequence

  2. XR_004937497.1 RNA Sequence

  3. XR_004937495.1 RNA Sequence

  4. XR_004937496.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59764.1 GenPept UniProtKB/Swiss-Prot:P59764

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