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MAPRE3 microtubule associated protein RP/EB family member 3 [ Homo sapiens (human) ]

Gene ID: 22924, updated on 3-Apr-2024

Summary

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Official Symbol
MAPRE3provided by HGNC
Official Full Name
microtubule associated protein RP/EB family member 3provided by HGNC
Primary source
HGNC:HGNC:6892
See related
Ensembl:ENSG00000084764 MIM:605788; AllianceGenome:HGNC:6892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EB3; RP3; EBF3; EBF3-S
Summary
The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 45.3), testis (RPKM 13.7) and 20 other tissues See more
Orthologs
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Genomic context

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See MAPRE3 in Genome Data Viewer
Location:
2p23.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (26970637..27027219)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27012305..27068902)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27193505..27250087)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dihydropyrimidinase like 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15480 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:27135238-27135875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27136064-27137020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27157221-27157720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27172437-27172937 Neighboring gene uncharacterized LOC124905979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15481 Neighboring gene MAPRE3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27247061-27247851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15482 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27261678-27262877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11279 Neighboring gene transmembrane protein 214 Neighboring gene AGBL5 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NMR resonance assignment and structure prediction of the C-terminal domain of the microtubule end-binding protein 3. Abdelkarim H, et al. PLoS One, 2020. PMID 32421702, Free PMC Article
  2. The drebrin/EB3 pathway drives invasive activity in prostate cancer. Dart AE, et al. Oncogene, 2017 Jul 20. PMID 28319065, Free PMC Article
  3. Frameshift mutation of MAPRE3, a microtubule-related gene, in gastric and colorectal cancers with microsatellite instability. Kim YR, et al. Pathology, 2010. PMID 20632835
  4. Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Sohn PD, et al. Neuron, 2019 Nov 6. PMID 31542321, Free PMC Article
  5. Role of tau N-terminal motif in the secretion of human tau by End Binding proteins. Sayas CL, et al. PLoS One, 2019. PMID 30668577, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo.
    Title: MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo.
  2. structure prediction of the C-terminal domain of the microtubule end-binding protein 3
    Title: NMR resonance assignment and structure prediction of the C-terminal domain of the microtubule end-binding protein 3.
  3. Extracellular recordings revealed that the V337M tau mutation leads to an abnormal increase in neuronal activity in response to chronic depolarization. In neurons with this mutation, axon initial segment (AIS) plasticity is impaired by the abnormal accumulation of end-binding protein 3 (EB3) in the AIS submembrane region.
    Title: Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
  4. IP3K-A binds to EB3 and their binding affinity is precisely regulated by protein kinase A (PKA)-dependent phosphorylation of IP3K-A at Ser119 (pSer119). The complex of IP3K-A and EB3 dissociates and reassociates rapidly during chemically induced LTP.
    Title: PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3.
  5. One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 phosphorylation of drebrin but the upstream elements in the pathway have yet to be identified.
    Title: Phosphorylation of Drebrin and Its Role in Neuritogenesis.
  6. EB1 and EB3 thus affect multiple interphase processes and have a major impact on microtubule minus end organization.
    Title: EB1 and EB3 regulate microtubule minus end organization and Golgi morphology.
  7. Findings show that co-ordination of dynamic microtubules and actin filaments by the drebrin/EB3 pathway drives prostate cancer cell invasion and is therefore implicated in disease progression.
    Title: The drebrin/EB3 pathway drives invasive activity in prostate cancer.
  8. Aptamers binding to human EB1 and EB3, which have sequence requirements similar to but distinct from each other and from Drosophila EB1, were identified.
    Title: Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics.
  9. EB1 and EB3 proteins are obligatory dimers.
    Title: End binding proteins are obligatory dimers.
  10. Findings suggest that methylation-associated down-regulation of EBF3 and IRX1 genes may play an important role in a pathogenic effect of TGF-beta on RASFs.
    Title: Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitotic spindle astral microtubule end IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
microtubule-associated protein RP/EB family member 3
Names
APC binding protein
EB1 protein family member 3
end-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303050.2 → NP_001289979.1  microtubule-associated protein RP/EB family member 3 isoform 1

    See identical proteins and their annotated locations for NP_001289979.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AB025186, AC013472, BC011557, BM560331, HY011071
    Consensus CDS
    CCDS1731.1
    UniProtKB/Swiss-Prot
    B7WPK5, O00265, Q6FHB0, Q6FI15, Q9BZP7, Q9BZP8, Q9UPY8
    UniProtKB/TrEMBL
    B2R5W6
    Conserved Domains (1) summary
    COG5217
    Location:16 → 279
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

  2. NM_001410716.1 → NP_001397645.1  microtubule-associated protein RP/EB family member 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013472
    Consensus CDS
    CCDS92722.1
    Related
    ENSP00000383915.3, ENST00000405074.7

  3. NM_012326.4 → NP_036458.2  microtubule-associated protein RP/EB family member 3 isoform 1

    See identical proteins and their annotated locations for NP_036458.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AB025186, AC013472, BC011557, DC417465
    Consensus CDS
    CCDS1731.1
    UniProtKB/Swiss-Prot
    B7WPK5, O00265, Q6FHB0, Q6FI15, Q9BZP7, Q9BZP8, Q9UPY8
    UniProtKB/TrEMBL
    B2R5W6
    Related
    ENSP00000233121.2, ENST00000233121.7
    Conserved Domains (1) summary
    COG5217
    Location:16 → 279
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    26970637..27027219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443728.1 → XP_047299684.1  microtubule-associated protein RP/EB family member 3 isoform X1

    UniProtKB/Swiss-Prot
    B7WPK5, O00265, Q6FHB0, Q6FI15, Q9BZP7, Q9BZP8, Q9UPY8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    27012305..27068902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341040.1 → XP_054197015.1  microtubule-associated protein RP/EB family member 3 isoform X1

    UniProtKB/Swiss-Prot
    B7WPK5, O00265, Q6FHB0, Q6FI15, Q9BZP7, Q9BZP8, Q9UPY8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UPY8.1 GenPept UniProtKB/Swiss-Prot:Q9UPY8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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