Npbwr1 neuropeptides B/W receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npbwr1provided by MGI
Official Full Name: neuropeptides B/W receptor 1provided by MGI
Primary source: MGI:MGI:891989
See related: Ensembl:ENSMUSG00000033774 AllianceGenome:MGI:891989
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr7; Nbpwr1
Summary: Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Acts upstream of or within regulation of metabolic process. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human NPBWR1 (neuropeptides B and W receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 1 A1; 1 1.89 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (5983926..5987617, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (5913707..5917398, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The neuropeptide W (NPW) mRNA quickly elevated in the early differentiation (7-14 days) of ATDC5 cells, while NPW and neuropeptides B/W receptor 1 (GPR7) mRNA were reduced during the late stage (14-21 days) of differentiation.
Title: Neuropeptide W regulates proliferation and differentiation of ATDC5: Possible involvement of GPR7 activation, PKA and PKC-dependent signalling cascades.
Important roles of NPBWR1 in regulating amygdala function during physical and social stress.
Title: Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory.
data demonstrate that GPR7 mRNA showed a significant circadian rhythm in the suprachiasmatic nucleus showing a peak at early subjective night in both light-dark and constant dark
Title: Circadian characteristics of mice depleted with GPR7.
role for GPR7 and its endogenous ligands, neuropeptide B and neuropeptide W, in regulating energy homeostasis.
Title: Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuropeptides B/W receptor type 1

Names: G protein-coupled receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.