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Dzip3 DAZ interacting protein 3, zinc finger [ Mus musculus (house mouse) ]

Gene ID: 224170, updated on 5-Mar-2024

Summary

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Official Symbol
Dzip3provided by MGI
Official Full Name
DAZ interacting protein 3, zinc fingerprovided by MGI
Primary source
MGI:MGI:1917433
See related
Ensembl:ENSMUSG00000064061 AllianceGenome:MGI:1917433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2A-HUB; A230104G20; 2310047C04Rik; 6430549P11Rik
Summary
Predicted to enable several functions, including phosphatase binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in cytoplasm. Orthologous to human DZIP3 (DAZ interacting zinc finger protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 15.0), CNS E14 (RPKM 12.5) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B5; 16 30.75 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48744591..48814505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48924228..48994142, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene resistin like alpha Neighboring gene STARR-seq mESC enhancer starr_40961 Neighboring gene resistin like gamma Neighboring gene STARR-seq mESC enhancer starr_40962 Neighboring gene STARR-positive B cell enhancer mm9_chr16:48942004-48942304 Neighboring gene predicted gene, 22576 Neighboring gene STARR-seq mESC enhancer starr_40963 Neighboring gene STARR-seq mESC enhancer starr_40964 Neighboring gene cell proliferation regulating inhibitor of protein phosphatase 2A Neighboring gene myosin, heavy chain 15 Neighboring gene STARR-positive B cell enhancer mm9_chr16:49164447-49164748

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation. Inoue D, et al. Sci Rep, 2015 Nov 16. PMID 26568260, Free PMC Article
  2. Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-α. Purcell DJ, et al. Mol Endocrinol, 2015 Dec. PMID 26505218, Free PMC Article
  3. Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Zhou W, et al. Mol Cell, 2008 Jan 18. PMID 18206970, Free PMC Article
  4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dzip3, the E3 ligase of H2AK119, represses differentiation-inducible genes in mouse embryonic stem cells.
    Title: Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase DZIP3
Names
DAZ-interacting protein 3 homolog
RING-type E3 ubiquitin transferase DZIP3
NP_001103487.1
NP_001343354.1
NP_081617.1
XP_017172456.1
XP_030104951.1
XP_030104952.1
XP_030104953.1
XP_030104954.1
XP_036015793.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110017.2 → NP_001103487.1  E3 ubiquitin-protein ligase DZIP3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154447
    Consensus CDS
    CCDS49866.1
    UniProtKB/Swiss-Prot
    Q148V3, Q7TPV2, Q80TU4, Q8BYK7
    UniProtKB/TrEMBL
    E9QNZ2
    Related
    ENSMUSP00000113344.2, ENSMUST00000121869.8
    Conserved Domains (2) summary
    pfam12678
    Location:1143 → 1184
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:1144 → 1184
    zf-RING_2; Ring finger domain

  2. NM_001356425.1 → NP_001343354.1  E3 ubiquitin-protein ligase DZIP3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154447
    UniProtKB/Swiss-Prot
    Q148V3, Q7TPV2, Q80TU4, Q8BYK7
    Conserved Domains (2) summary
    cl17238
    Location:1143 → 1168
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl25732
    Location:744 → 931
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_027341.2 → NP_081617.1  E3 ubiquitin-protein ligase DZIP3 isoform 2

    See identical proteins and their annotated locations for NP_081617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes an isoform (2) which is shorter than isoform 1.
    Source sequence(s)
    AK163763, BC117954, CJ122641
    Consensus CDS
    CCDS37353.1
    UniProtKB/Swiss-Prot
    Q148V3, Q7TPV2, Q80TU4, Q8BYK7
    Related
    ENSMUSP00000110161.2, ENSMUST00000114516.8
    Conserved Domains (2) summary
    pfam12678
    Location:937 → 978
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:938 → 978
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    48744591..48814505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316967.2 → XP_017172456.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:538 → 725
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl17238
    Location:937 → 962
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_036159900.1 → XP_036015793.1  E3 ubiquitin-protein ligase DZIP3 isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:191 → 378
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5540
    Location:499 → 637
    COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16460
    Location:589 → 631
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins

  3. XM_030249092.1 → XP_030104952.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

    Conserved Domains (4) summary
    COG1196
    Location:397 → 584
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5540
    Location:705 → 843
    COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16460
    Location:795 → 837
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    pfam18738
    Location:74 → 217
    HEPN_DZIP3; DZIP3/ hRUL138-like HEPN

  4. XM_030249093.1 → XP_030104953.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

    Conserved Domains (4) summary
    COG1196
    Location:397 → 584
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5540
    Location:705 → 843
    COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16460
    Location:795 → 837
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    pfam18738
    Location:74 → 217
    HEPN_DZIP3; DZIP3/ hRUL138-like HEPN

  5. XM_030249094.1 → XP_030104954.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:291 → 478
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5540
    Location:599 → 737
    COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16460
    Location:689 → 731
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins

  6. XM_030249091.1 → XP_030104951.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

    Conserved Domains (4) summary
    COG1196
    Location:497 → 684
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5540
    Location:805 → 943
    COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16460
    Location:895 → 937
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    pfam18738
    Location:174 → 317
    HEPN_DZIP3; DZIP3/ hRUL138-like HEPN

RNA

  1. XR_001781815.2 RNA Sequence

  2. XR_001781814.2 RNA Sequence

  3. XR_003951784.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPV2.2 GenPept UniProtKB/Swiss-Prot:Q7TPV2

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