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Slc16a11 solute carrier family 16 (monocarboxylic acid transporters), member 11 [ Mus musculus (house mouse) ]

Gene ID: 216867, updated on 3-Apr-2024

Summary

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Official Symbol
Slc16a11provided by MGI
Official Full Name
solute carrier family 16 (monocarboxylic acid transporters), member 11provided by MGI
Primary source
MGI:MGI:2663709
See related
Ensembl:ENSMUSG00000040938 AllianceGenome:MGI:2663709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCT 11; MNCb-2717
Summary
Predicted to enable pyruvate transmembrane transporter activity. Predicted to be involved in lipid metabolic process and monocarboxylic acid transport. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human SLC16A11 (solute carrier family 16 member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 54.4), cerebellum adult (RPKM 29.8) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 42.99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70104717..70107239)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70213695..70216414)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12311 Neighboring gene macrophage galactose N-acetyl-galactosamine specific lectin 2 Neighboring gene STARR-seq mESC enhancer starr_29870 Neighboring gene C-type lectin domain family 10, member A Neighboring gene STARR-seq mESC enhancer starr_29871 Neighboring gene STARR-seq mESC enhancer starr_29872 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 13 Neighboring gene B cell CLL/lymphoma 6, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adeno-Associated Virus-Mediated Knockdown of SLC16A11 Improves Glucose Tolerance and Hepatic Insulin Signaling in High Fat Diet-Fed Mice. Zhang T, et al. Exp Clin Endocrinol Diabetes, 2021 Feb. PMID 31185508
  2. Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes. Zhao Y, et al. Cell Rep, 2019 Jan 22. PMID 30673611
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adeno-Associated Virus-Mediated Knockdown of SLC16A11 Improves Glucose Tolerance and Hepatic Insulin Signaling in High Fat Diet-Fed Mice.
    Title: Adeno-Associated Virus-Mediated Knockdown of SLC16A11 Improves Glucose Tolerance and Hepatic Insulin Signaling in High Fat Diet-Fed Mice.
  2. Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
    Title: Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 11
Names
novel RNA polymerase Rpb1 C-terminal repeat domain containing protein
solute carrier family 16 member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416062.1 → NP_001402991.1  monocarboxylate transporter 11

    Status: VALIDATED

    Source sequence(s)
    AL669869
    UniProtKB/Swiss-Prot
    A2BDD4, Q5NC32, Q5NC33
    Related
    ENSMUSP00000091597.4, ENSMUST00000094055.10

  2. NM_001416063.1 → NP_001402992.1  monocarboxylate transporter 11

    Status: VALIDATED

    Source sequence(s)
    AL669869
    UniProtKB/Swiss-Prot
    A2BDD4, Q5NC32, Q5NC33

  3. NM_153081.4 → NP_694721.2  monocarboxylate transporter 11

    See identical proteins and their annotated locations for NP_694721.2

    Status: VALIDATED

    Source sequence(s)
    AL669869
    UniProtKB/Swiss-Prot
    A2BDD4, Q5NC32, Q5NC33
    UniProtKB/TrEMBL
    B7ZCB5
    Related
    ENSMUSP00000128419.2, ENSMUST00000171032.8
    Conserved Domains (1) summary
    cl28910
    Location:14 → 403
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70104717..70107239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001114970.1: Suppressed sequence

    Description
    NM_001114970.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_001114971.1: Suppressed sequence

    Description
    NM_001114971.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NC32.1 GenPept UniProtKB/Swiss-Prot:Q5NC32

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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