U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc45a3 solute carrier family 45, member 3 [ Mus musculus (house mouse) ]

Gene ID: 212980, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Slc45a3provided by MGI
Official Full Name
solute carrier family 45, member 3provided by MGI
Primary source
MGI:MGI:1922082
See related
Ensembl:ENSMUSG00000026435 AllianceGenome:MGI:1922082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRST; IPCA-6; Pcanap6; 2210413P12Rik
Summary
Enables sucrose:proton symporter activity. Involved in positive regulation of fatty acid biosynthetic process; positive regulation of glucose metabolic process; and regulation of oligodendrocyte differentiation. Acts upstream of or within sucrose transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Orthologous to human SLC45A3 (solute carrier family 45 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 64.4), stomach adult (RPKM 39.0) and 11 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 E4; 1 57.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131890653..131910710)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131962915..131982972)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5799 Neighboring gene STARR-seq mESC enhancer starr_02227 Neighboring gene RAB29, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_02228 Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:133879500-133879800 Neighboring gene STARR-positive B cell enhancer ABC_E5800 Neighboring gene STARR-positive B cell enhancer ABC_E5801 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133904735-133904947 Neighboring gene STARR-positive B cell enhancer ABC_E10036 Neighboring gene STARR-positive B cell enhancer ABC_E11086 Neighboring gene STARR-positive B cell enhancer ABC_E5802 Neighboring gene ELK4, member of ETS oncogene family Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene RIKEN cDNA 4833413N01 gene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DNA microarray analysis of region-specific gene expression in the mouse epididymis. Hsia N, et al. Biol Reprod, 2004 Feb. PMID 14561649
  2. miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin. Shin D, et al. Neuroscience, 2012 Jun 28. PMID 22521588, Free PMC Article
  3. Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. Bartölke R, et al. Biochem J, 2014 Dec 1. PMID 25164149
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC32471

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables sucrose:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sucrose:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sucrose transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
solute carrier family 45 member 3
Names
Prostein
prostate cancer-associated protein 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177628.2 → NP_001171099.1  solute carrier family 45 member 3

    See identical proteins and their annotated locations for NP_001171099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC107837, AK035428, BY713333
    Consensus CDS
    CCDS15278.1
    UniProtKB/Swiss-Prot
    Q8K0H7, Q8K252, Q8R1I0
    Related
    ENSMUSP00000136190.2, ENSMUST00000177943.8
    Conserved Domains (1) summary
    cd17313
    Location:18 → 537
    MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

  2. NM_145977.2 → NP_666089.1  solute carrier family 45 member 3

    See identical proteins and their annotated locations for NP_666089.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC107837
    Consensus CDS
    CCDS15278.1
    UniProtKB/Swiss-Prot
    Q8K0H7, Q8K252, Q8R1I0
    Related
    ENSMUSP00000027695.7, ENSMUST00000027695.8
    Conserved Domains (1) summary
    cd17313
    Location:18 → 537
    MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131890653..131910710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529341.3 → XP_006529404.1  solute carrier family 45 member 3 isoform X1

    See identical proteins and their annotated locations for XP_006529404.1

    UniProtKB/Swiss-Prot
    Q8K0H7, Q8K252, Q8R1I0
    Conserved Domains (1) summary
    cd17313
    Location:18 → 537
    MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

  2. XM_006529342.3 → XP_006529405.1  solute carrier family 45 member 3 isoform X1

    See identical proteins and their annotated locations for XP_006529405.1

    UniProtKB/Swiss-Prot
    Q8K0H7, Q8K252, Q8R1I0
    Conserved Domains (1) summary
    cd17313
    Location:18 → 537
    MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0H7.1 GenPept UniProtKB/Swiss-Prot:Q8K0H7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous