Your browser version may not work well with NCBI's Web applications. More information here...

1: E2F3 E2F transcription factor 3 [ Homo sapiens ]

GeneID: 1871 updated 21-Dec-2009

[Top][Help]Summary

Official Symbol
E2F3provided by HGNC
Official Full Name
E2F transcription factor 3provided by HGNC
Primary Source
HGNC:3115
Locus Tag
RP1-177P22.2
See related
Ensembl:ENSG00000112242; HPRD:02693; MIM:600427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E2F-3; KIAA0075; MGC104598; DKFZp686C18211; E2F3
Summary
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 6; Location: 6p22See E2F3 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. miR-128 can inhibit proliferation of glioma cells through one of its targets, E2F3a.
PubMed 2. report confirms significant mRNA overexpression of KIF14 and E2F3 together in a large cohort of retinoblastoma tumors
PubMed 3. A significant elevation in expression of E2F3 in oral squamous cell carcinoma cells was seen in carbon and neon-irradiated cells.
PubMed 4. E2F3 modulates Aurora-A mRNA expression during the cell cycle.
PubMed 5. E2F3 gain is associated with the late stage of retinoblastoma.
PubMed 6. Expression of E2F3 was lowest in early-stage tumors and highest in metastatic tissue. Expression profiling of miRNAs in WT showed that expression of each measured member of the Oncomir-1 family was highest in WT relative to other kidney tumor subtypes
PubMed 7. Genes involved in the E2F3 pathway are associated with chemotherapy sensitivity among ER- tumors. The mutant p53 signature and expression of ER-related genes were associated with lower sensitivity to chemotherapy in ER+ breast tumors only.
PubMed 8. Inactivation of the retinoblastoma pathway occurs in bladder tumors with 6p22 amplification.
PubMed 9. E2F3 contributes to ataxia telangiectasia mutated (ATM) kinase-dependent p53 phosphorylation and apoptosis in cells expressing E1A.
PubMed 10. requirement of E2F3 for BCR/ABL leukemogenesis
PubMed 11. Study demonstrates the strength of E2F3 as a potential marker for discriminating benign and malignant disease, addressing the current limitations of serum PSA measurements.
PubMed 12. Data suggest that the physical interaction of TFE3 and E2F3 facilitates transcriptional activation of the p68 gene and provides strong evidence for the specificity of E2F function.
PubMed 13. results suggest that DEK and E2F3 are potential targets of 6p gains in retinoblastoma
PubMed 14. E2F3 is overexpressed in 55-70% of squamous cell carcinomas and 79% of adenocarcinomas of the lung. In addition very high level expression of nuclear E2F3 is found in almost all small cell lung cancers analysed.
PubMed 15. In bladder cancer, the E2F3 gene is associated with overexpression of its encoded mRNA transcripts and high levels of E2F3 expression.
PubMed 16. We conclude that E2F3 is frequently amplified and overexpressed in invasively growing bladder cancer (stage pT1-4). E2F3 expression appears to provide a growth advantage to tumor cells by activating cell proliferation in a subset of bladder tumors.
PubMed 17. determination of interaction with RYBP and YY1
PubMed 18. E2F3 levels have a critical role in modifying cellular proliferation rate in human bladder and prostate cancer.
PubMed 19. E2F1, E2F2, and E2F3 directly bind the promoter of the mir-17-92 cluster, activating its transcription. miR-20a from the mir-17-92 cluster in turn modulates the translation of E2F2 and E2F3, suggesting an autoregulatory feedback loop.
PubMed 20. E2F3 mRNA and protein are overexpressed in retinoblastoma.
Submit: New GeneRIF Correction

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
E2F3 (E2F-3) interacts with the BIRC5 (survivin) promoter.
  NP_001940.1   U75285.1   BIRC5      BIND    PubMed
E2F3 interacts with the Cdc25A promoter.
  NP_001940.1   NC_000003.9   CDC25A      BIND    PubMed
E2F3 interacts with the Cdc6 promoter.
  NP_001940.1   NC_000017.9   CDC6      BIND    PubMed
E2F3 interacts with the Cdc2 promoter.
  NP_001940.1   NC_000010.8   CDK1      BIND    PubMed
E2F3 interacts with EAPP.
  NP_001940.1   AAX63200.1   EAPP      BIND    PubMed
E2F3 interacts with a molecule expressed by Gene FHL2. The precise molecular variant of FHL2 involved in this interaction is not specified.
  NP_001940.1      FHL2      BIND    PubMed
The Gab2 promoter region interacts with E2F3.
  NP_001940.1   NC_000011.8   GAB2      BIND    PubMed
E2F3 interacts with the JMY promoter.
  NP_001940.1   NC_000005.8   JMY      BIND    PubMed
E2F3 interacts with the MSH2 promoter.
  NP_001940.1   NC_000002.9   MSH2      BIND    PubMed
E2F3 interacts with the MT1G promoter.
  NP_001940.1   J03910.1   MT1G      BIND    PubMed
E2F3 interacts with the B-myb promoter region.
  NP_001940.1   NC_000020.9   MYBL2      BIND    PubMed
E2F3 interacts with the PPP1R13B (ASPP1) promoter.
  NP_001940.1   NC_000014.7   PPP1R13B      BIND    PubMed
E2F3 interacts with RYBP.
  NP_001940.1   NP_036366.2   RYBP      BIND    PubMed
E2F3 interacts with the TP53BP2 (ASPP2) promoter.
  NP_001940.1   NC_000001.8   TP53BP2      BIND    PubMed
E2F3 interacts with the TP53INP1 promoter.
  NP_001940.1   NC_000008.9   TP53INP1      BIND    PubMed
E2F3 interacts with the UXT chromatin.
  NP_001940.1   NC_000023.8   UXT      BIND    PubMed
E2F-3 interacts with the E2F site. This interaction was modelled on a demonstrated interaction between E2F-3 and a synthetic dsDNA construct.
  NP_001940.1           BIND    PubMed
 
  O00716   P20248   CCNA2      HPRD    PubMed
 
  O00716   Q00526   CDK3      HPRD    PubMed
 
  O00716   P06400   RB1      HPRD    PubMed
 
  O00716   Q8N488   RYBP      HPRD    PubMed
 
  O00716   P08047   SP1      HPRD    PubMed
 
  O00716   Q14186   TFDP1      HPRD    PubMed
 
  O00716   Q14188   TFDP2      HPRD    PubMed
 
  O00716   P19532   TFE3      HPRD    PubMed
 
  O00716   P25490   YY1      HPRD    PubMed
Two-hybrid
  BioGRID:108203   BioGRID:107777   CREBBP      BioGRID    PubMed
Two-hybrid
  BioGRID:108203   BioGRID:108565   FHL2      BioGRID    PubMed
Two-hybrid
  BioGRID:108203   BioGRID:116870   MGA      BioGRID    PubMed
Two-hybrid
  BioGRID:108203   BioGRID:110690   MYBL2      BioGRID    PubMed
Two-hybrid
  BioGRID:108203   BioGRID:111557   PKIB      BioGRID    PubMed
Two-hybrid
  BioGRID:108203   BioGRID:115125   RNF144A      BioGRID    PubMed
Affinity Capture-Western; Two-hybrid
  BioGRID:108203   BioGRID:116997   RYBP      BioGRID    PubMed
Two-hybrid
  BioGRID:108203   BioGRID:112567   SPIB      BioGRID    PubMed
Reconstituted Complex
  BioGRID:108203   BioGRID:203414   Sp1      BioGRID    PubMed
Two-hybrid
  BioGRID:108203   BioGRID:112864   TEAD3      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:108203   BioGRID:112888   TFE3      BioGRID    PubMed
Two-hybrid
  BioGRID:108203   BioGRID:122403   WNK1      BioGRID    PubMed

[Top][Help]General gene information

Markers

WI-22629(e-PCR)
Links: UniSTS:13059
RH17438(e-PCR)
Links: UniSTS:90147
PMC85656P1(e-PCR)
Links: UniSTS:273486
RH25304(e-PCR)
Links: UniSTS:92248
G67592(e-PCR)
Links: UniSTS:224121
RH36412(e-PCR)
Links: UniSTS:40842
D6S1943(e-PCR)
Links: UniSTS:33780
RH45318(e-PCR)
Links: UniSTS:24829

Related pseudogene(s)

2 foundReview record(s) in Gene

Homology

Homologs of the E2F3 gene The E2F3 gene is conserved in cow, mouse, rat, and chicken.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Bladder cancer
05219
KEGG pathway: Cell cycle
04110
KEGG pathway: Chronic myeloid leukemia
05220
KEGG pathway: Glioma
05214
KEGG pathway: Melanoma
05218
KEGG pathway: Non-small cell lung cancer
05223
KEGG pathway: Pancreatic cancer
05212
KEGG pathway: Pathways in cancer
05200
KEGG pathway: Prostate cancer
05215
KEGG pathway: Small cell lung cancer
05222
Reactome Event:Cell Cycle, Mitotic
REACT_152

[Top][Help]General protein information

Preferred Names
E2F transcription factor 3
Names
E2F transcription factor 3

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_001949.3 → NP_001940.1  E2F transcription factor 3

    Source sequence(s)
    BC099908,D38550,W38841,Y10479
    Consensus CDS
    CCDS4545.1
    UniProtKB/Swiss-Prot
    O00716
    UniProtKB/TrEMBL
    Q499G5
    Related Ensembl
    ENSP00000262904, ENST00000346618
    Conserved Domains (1) summary
    pfam02319
    Location:178 – 243
    Blast Score: 295
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000006.11

    Range
    20402136..20493944
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_007592.15 

    Range
    20342136..20433944
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000049.1

    Range
    21635266..21727061
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_922984.1 

    Range
    20030522..20122317
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000138.1

    Range
    20346528..20438218
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838973.1 

    Range
    16691565..16783255
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AF547386.1   AAN17846.1
  genomic   AL132775.29   CAI21471.1
  genomic   AL136303.15   CAC28598.2
  genomic   CH471087.1   EAW55421.1
       EAW55422.1
       EAW55423.1
  mRNA   BC016847.1   AAH16847.1
  mRNA   BC099908.1   AAH99908.1
  mRNA   BC114554.1   AAI14555.1
  mRNA   CR597993.1   None
  mRNA   CR749285.1   CAH18140.1
  mRNA   D38550.1   BAA07553.1
  mRNA   W38841.1   None
  mRNA   Y10479.1   CAA71504.1
  other-genetic   BC156367.1   AAI56368.1
  other-genetic   BC172526.1   AAI72526.1
Protein Accession   Links
O00716.1   GenPept   UniProtKB/Swiss-Prot:O00716
Q24JQ3   GenPept   UniProtKB/TrEMBL:Q24JQ3
Q499G5   GenPept   UniProtKB/TrEMBL:Q499G5
Q68DT0   GenPept   UniProtKB/TrEMBL:Q68DT0
Q96AR0   GenPept   UniProtKB/TrEMBL:Q96AR0

[Top][Help]Additional Links