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asp-4 Aspartic protease 4 [ Caenorhabditis elegans ]

Gene ID: 181444, updated on 3-Mar-2024

Summary

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Gene symbol
asp-4
Gene description
Aspartic protease 4
Primary source
WormBase:WBGene00000217
Locus tag
CELE_R12H7.2
See related
AllianceGenome:WB:WBGene00000217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aspartic-type endopeptidase activity. Involved in necrotic cell death and proteolysis. Located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension (multiple); neuronal ceroid lipofuscinosis 10; and portal hypertension. Orthologous to several human genes including CTSD (cathepsin D). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (13218985..13221462, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Innexin;Innexin unc-9 Neighboring gene G_PROTEIN_RECEP_F2_4 domain-containing protein Neighboring gene Skp1-related protein Neighboring gene Skp1-related protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metabolic labeling of Caenorhabditis elegans primary embryonic cells with azido-sugars as a tool for glycoprotein discovery. Burnham-Marusich AR, et al. PLoS One, 2012. PMID 23152843, Free PMC Article
  2. A Disease Model of Muscle Necrosis Caused by Aeromonas dhakensis Infection in Caenorhabditis elegans. Chen PL, et al. Front Microbiol, 2016. PMID 28101079, Free PMC Article
  3. Proteolytic mechanisms in necrotic cell death and neurodegeneration. Artal-Sanz M, et al. FEBS Lett, 2005 Jun 13. PMID 15943973
  4. Execution of Necrotic-Like Cell Death in Caenorhabditis elegans Requires Cathepsin D Activity. Tavernarakis N, et al. ScientificWorldJournal, 2001. PMID 30147617, Free PMC Article
  5. First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6. Lochnit G, et al. Biol Chem, 2006 Oct-Nov. PMID 17081123

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartic-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell death IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in programmed necrotic cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aspartic protease 4
NP_510191.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13218985..13221462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077790.8 → NP_510191.1  Aspartic protease 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510191.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21966
    Conserved Domains (1) summary
    cl11403
    Location:88 → 411
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21966.1

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