pdi-2 Protein disulfide-isomerase 2 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: pdi-2
Gene description: Protein disulfide-isomerase 2
Primary source: WormBase:WBGene00003963
Locus tag: CELE_C07A12.4
See related: AllianceGenome:WB:WBGene00003963
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein disulfide isomerase activity and protein-glutamine gamma-glutamyltransferase activity. Contributes to peptidyl-proline 4-dioxygenase activity. Involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline and protein deglutathionylation. Located in endoplasmic reticulum. Part of procollagen-proline 4-dioxygenase complex. Is expressed in several structures, including germ line and hypodermis. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to several human genes including P4HB (prolyl 4-hydroxylase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (4524155..4526536)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pdi-1, pdi-2, and pdi-3 have comparable kinetic properties in catalyzing thiol-disulfide exchange reactions in two simple peptide-based assays. However, the three enzymes exhibited clear differences in their reactivity towards protein substrates.
Title: Protein disulfide isomerases from C. elegans are equally efficient at thiol-disulfide exchange in simple peptide-based systems but show differences in reactivity towards protein substrates.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C07A12.4 (e-PCR)
- UniSTS:308981

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
contributes_to peptidyl-proline 4-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein disulfide isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein-glutamine gamma-glutamyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	HEP more info	PubMed
involved_in macromolecule modification	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deglutathionylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
part_of procollagen-proline 4-dioxygenase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Protein disulfide-isomerase 2

NP_508778.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4524155..4526536

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076377.6 → NP_508778.1 Protein disulfide-isomerase 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508778.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17770

Conserved Domains (5) summary

cd02981
Location:133 → 228

PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...

cd02982
Location:240 → 343

PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...

cd02995
Location:364 → 465

PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...

TIGR01126
Location:28 → 129

pdi_dom; protein disulfide-isomerase domain

TIGR01130
Location:23 → 471

ER_PDI_fam; protein disulfide isomerase, eukaryotic