Mrc2 mannose receptor, C type 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrc2provided by MGI
Official Full Name: mannose receptor, C type 2provided by MGI
Primary source: MGI:MGI:107818
See related: Ensembl:ENSMUSG00000020695 AllianceGenome:MGI:107818
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: uPARAP; Endo180; mKIAA0709
Summary: Predicted to enable carbohydrate binding activity; collagen binding activity; and signaling receptor activity. Predicted to be involved in collagen catabolic process. Predicted to act upstream of or within endocytosis. Predicted to be located in cell surface. Is expressed in several structures, including brain; head bone; meninges; metanephros; and respiratory system. Orthologous to human MRC2 (mannose receptor C type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 31.6), lung adult (RPKM 31.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 68.73 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (105183440..105241971)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (105292093..105351146)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1.
Title: The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1.
Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis.
Title: Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis.
MiR-23b-3p promotes postmenopausal osteoporosis by targeting MRC2 and regulating the Wnt/beta-catenin signaling pathway.
Title: MiR-23b-3p promotes postmenopausal osteoporosis by targeting MRC2 and regulating the Wnt/β-catenin signaling pathway.
Fibroblast-specific expression of uPARAP governed endogenous SP-D levels and overall survival after lung injury.
Title: Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.
uPARAP controlVEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.
Title: uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.
Findings show that under in vivo conditions, uPARAP does not play a role in the phagocytic uptake of collagen fibrils by fibroblasts.
Title: Phagocytosis of Collagen Fibrils by Fibroblasts In Vivo Is Independent of the uPARAP/Endo180 Receptor.
Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma
Title: Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.
AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression.
Title: AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.
uPARAP function in cutaneous wound repair
Title: uPARAP function in cutaneous wound repair.
Both uPARAP and MMP-2 take part in matrix turnover processes important for bone growth.
Title: Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140464 (e-PCR)
- UniSTS:222538

MARC_26180-26181:1030714398:1 (e-PCR)
- UniSTS:268973

Mrc2 (e-PCR), detects polymorphism
- UniSTS:519404

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info	PubMed
enables collagen binding	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: C-type mannose receptor 2

Names: lectin lambda; macrophage mannose receptor 2; novel lectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008626.3 → NP_032652.3 C-type mannose receptor 2 precursor

See identical proteins and their annotated locations for NP_032652.3

Status: VALIDATED

Source sequence(s)

AL645684, BB665946, BC116642, BU053305

Consensus CDS

CCDS25539.1

UniProtKB/Swiss-Prot

A2AAB0, Q64449, Q6ZQ64, Q8C6P0

UniProtKB/TrEMBL

Q14AX9

Related

ENSMUSP00000097909.4, ENSMUST00000100335.10

Conserved Domains (4) summary

smart00059
Location:179 → 227

FN2; Fibronectin type 2 domain

cd00037
Location:246 → 360

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00034
Location:381 → 504

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:45 → 160

RICIN; Ricin-type beta-trefoil

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

105183440..105241971

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532406.5 → XP_006532469.1 C-type mannose receptor 2 isoform X1

UniProtKB/TrEMBL

Q14AX9

Conserved Domains (4) summary

smart00059
Location:214 → 262

FN2; Fibronectin type 2 domain

cd00037
Location:281 → 395

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00034
Location:416 → 539

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:80 → 195

RICIN; Ricin-type beta-trefoil